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FLASH GENE
Symbol RPS6 contributors: npt/mct - updated : 07-11-2018
HGNC name ribosomal protein S6
HGNC id 10429
Location 9p22.1      Physical location : 19.376.253 - 19.380.235
Synonym name
  • phosphoprotein NP33
  • 40S ribosomal protein S6
  • Synonym symbol(s) p70, S6K, S6
    DNA
    TYPE functioning gene
    STRUCTURE 3.98 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status confirmed
    Map pter - D9S157 - D9S1684 - D9S162 - RPS6 - MLLT3 - IFN1@ ,D9S736 ,D9S1749 ,D9S1751 ,D9S1748 ,D9S1752 - CDKN2A ,CDKN2B - D9S942 - D9S966 - CNTFR - cen
    Authors Bouzyk (97)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 829 - 249 - 1992 1446836
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
  • ribosomal protein S6e family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • structural component of the ribosome
  • basic FUNCTION
  • 40S ribosomal protein S6, housekeeping gene
  • having an essential role for proliferation in all cells (Robledo 2008)
  • selective mediator of TRAIL-apoptotic signaling (especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis)(Jeon 2008)
  • plays a positive role in controlling pancreatic beta-cell size and function (Moore 2009)
  • RPS6 in the MTOR pathway regulates blood-testis barrier (BTB) restructuring via its effects on the F-actin organization and protein recruitment at the BTB
  • FOS and RPS6 are induced by the biochemical activation of neurons, and therefore, these markers may be most responsive to stimuli that modulate neurons such as neuro-peptides and biogenic amines
  • RPS6-specific spatiotemporal pattern that is deregulated under conditions of hyperactivated MTOR
  • is a convergence point of cardioprotective signaling, providing positive feedback regulation of CRTC2/AKT1 signaling
  • aggregation of RPS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase
  • possible role of RPS6 phosphorylation in regulating postsynaptic protein synthesis during induction of synaptic plasticity
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • INTERACTION
    DNA
    RNA
    small molecule
  • ATP
  • protein
  • downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of RPS6
  • phosphorylation of RPS6 confers PARP1 inhibitor resistance in BRCA1-deficient cancers
  • SESN2 may regulate RPS6, a molecule important for protein synthesis, through the effect of MTOR complex that is pivotal for longevity
  • cell & other
    REGULATION
    activated by glucose in beta-cells, contributing to an increase in mitogenesis (Briaud 2003)
    Other phosphorylation of RPS6 can be used as a tag to enable the capture of mRNA from activated cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary diffuse large B-cell lymphoma (DLBCL), and associates with mRNA containing a 5prime terminal oligopyrimidine tract (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • combined detection of phosphorylated and non-phosphorylated RPS6 could represent a robust prognostic marker to identify patients with high risk renal cell carcinomas (RCCs)
  • Therapy target
    ANIMAL & CELL MODELS