basic FUNCTION
| 40S ribosomal protein involved in the repair of |
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oxidative DNA lesions |
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having an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage |
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involved in induction of apoptosis |
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functioning as a ribosomal protein but, in addition, may influence repair activities at sites of DNA damage |
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plays a role in repairing various DNA damage acting as a repair UV endonuclease  |
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free RPS3 can regulates its own translation via a feedback mechanism  |
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protecting against UV-induced skin cell death |
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ribosomal protein of the 40 S subunit, required for ribosome biogenesis extraribosomal  |
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role of RPS3 as a molecular switch that accommodates apoptotic induction to DNA repair through Akt-mediated phosphorylation  |
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may act upstream of caspase-3, most likely in the mitochondrial apoptotic pathway  |
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RPS3 is recruited to the DISC and plays a critical role in both genotoxic stress and cytokine induced apoptosis  |
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has multi-functions such as translation, DNA repair and apoptosis  |
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acts as a microtubule associated protein (MAP) and regulates spindle dynamics during mitosis |