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FLASH GENE
Symbol RPS3 contributors: mct - updated : 14-02-2014
HGNC name ribosomal protein S3
HGNC id 10420
Location 11q13.4      Physical location : 75.110.561 - 75.116.730
Synonym name 40S ribosomal protein S3, 26kDa, see RNU15A
Synonym symbol(s) FLJ26283, FLJ27450, MGC87870
DNA
TYPE functioning gene
SPECIAL FEATURE
text cotranscribed with RNU15A, RNU15B, embedded in introns 1 and 5, and RNU14
STRUCTURE 6.17 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 855 26 243 - 2004 14988002
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
Lymphoid/Immunelymph node   highly
 tonsils   highly
Reproductivefemale systemuteruscervix highly
 female systemovary  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text kidney, umbilical cord, embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a KH type-2 domain
  • C terminal domain, the major mRNA binding domain of RPS3, independent of the KH domain
  • HOMOLOGY
    interspecies homolog to rattus Rps3 (99.59 pc)
    homolog to murine Rps3 (99.59 pc)
    Homologene
    FAMILY
  • ribosomal protein S3P family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    text
  • dynamic protein that shuttles between the cytoplasm and the nucleus and functions in both compartments
  • nuclear accumulation of RPS3 results in an increase in DNA repair activity to some extent, thereby sustaining neuronal survival
  • basic FUNCTION
  • 40S ribosomal protein involved in the repair of
  • oxidative DNA lesions
  • having an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage
  • involved in induction of apoptosis
  • functioning as a ribosomal protein but, in addition, may influence repair activities at sites of DNA damage
  • plays a role in repairing various DNA damage acting as a repair UV endonuclease
  • free RPS3 can regulates its own translation via a feedback mechanism
  • protecting against UV-induced skin cell death
  • ribosomal protein of the 40 S subunit, required for ribosome biogenesis extraribosomal
  • role of RPS3 as a molecular switch that accommodates apoptotic induction to DNA repair through Akt-mediated phosphorylation
  • may act upstream of caspase-3, most likely in the mitochondrial apoptotic pathway
  • RPS3 is recruited to the DISC and plays a critical role in both genotoxic stress and cytokine induced apoptosis
  • has multi-functions such as translation, DNA repair and apoptosis
  • acts as a microtubule associated protein (MAP) and regulates spindle dynamics during mitosis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, repair
    nucleotide, genomic integrity
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • of the ribosome
  • component of NFKppaB complex, involved in the regulation of key genes
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • multi-functional protein that interacts with both TP53 and MDM2 through its KH domain, acted as a scaffold for the additional binding of MDM2 and TP53, suggesting that it interacts with important proteins involved in maintaining genomic integrity (MID: 19656744)
  • physiological target of AKT1 kinase and a novel mediator of neuronal apoptosis (AKT1-dependent phosphorylation of RPS3 inhibited its proapoptotic function and perturbed its interaction with E2F1)
  • RPS3 appears to be recruited to the death-inducing signaling complex (DISC) to induce apoptosis by interacting TRADD in response to extracellular stresses
  • cell & other
    REGULATION
    Other AKT1 phosphorylation governs RPS3 nuclear accumulation that in turn impairs its apoptotic function thereby promoting cell survival (
    arginine methylation of RPS3 plays a critical role in its import into the nucleolus, as well as in small subunit assembly of the ribosome
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    phosphorylation by AKT1 may provide useful clues in the development of novel treatments for neurological diseases
    ANIMAL & CELL MODELS