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FLASH GENE

Symbol

RPS26

contributors: mct/npt - updated : 11-01-2023

HGNC name	ribosomal protein S26
HGNC id	10414

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DBA10 Diamond-Blackfan anemia 10
Location	12q13.2      Physical location : 56.435.685 - 56.438.005
Synonym name	40S ribosomal protein S26
	small ribosomal subunit protein eS26
Synonym symbol(s)	MGC104292, DBA10, S26, eS26

DNA

TYPE	functioning gene
STRUCTURE	2.78 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001029 4 - 1140 NP_001020 - 115 - 2021 33908345

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils       highly Reproductive female system ovary     highly Homo sapiens   male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal tail of RPS26 is required for binding to TSR2

HOMOLOGY

Homologene

FAMILY

ribosomal protein S26e family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome

basic FUNCTION	40S ribosomal protein S26
	contribute to pre-rRNA processing (Doherty 2010)
	role of RPS26 in DNA damage response by directly influencing TP53 transcriptional activity, suggesting that RPS26 acts distinctively in different scenarios of TP53 activation
	RPS26 contributes to mRNA-specific translation by recognition of the Kozak sequence in well-translated mRNAs and RPS26-deficient ribosomes preferentially translate mRNA from select stress-response pathways
	is an indispensable component of the small (40S) ribosomal subunit and, along with other ribosomal proteins, is involved in interaction with mRNAs during translation
	RPS26 is released from preexisting mature ribosomes to yield RPS26-deficient ribosomes under high Na+ (or sorbitol) stress

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the small 40S ribosomal subunit

INTERACTION

DNA

RNA

binding

small molecule

protein	RPS26 has the ability to interact with MDM2 and inhibits MDM2-mediated TP53 ubiquitination that leads to TP53 stabilization upon overexpression
	is involved in the formation of a nucleophosmin binding site on the human 40S ribosomal subunit
	TSR2 releases RPS26 in the presence of high Na+ or pH in vitro and is required for RPS26 release in vivo

cell & other

interact with its pre-mRNA intron I and mRNA fragment (suppresses the splicing of its pre-mRNA)

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DBA10

Susceptibility

to type 1 diabetes (Schadt 2008) to polycystic ovary syndrome (PCOS)

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

specific knockout of Rps26 in mouse oocytes resulted in retarded follicle development from pre-antral follicles to antral follicles, while the chromatin configurations of the oocytes were arrested