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FLASH GENE
Symbol RPS26 contributors: mct/npt - updated : 05-03-2010
HGNC name ribosomal protein S26
HGNC id 10414
Corresponding disease
DBA10 Diamond-Blackfan anemia 10
Location 12q13.2      Physical location : 56.435.685 - 56.438.005
Synonym name 40S ribosomal protein S26
Synonym symbol(s) MGC104292
DNA
TYPE functioning gene
STRUCTURE 2.32 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
RDH5 12q13-q14 retinol dehydrogenase 5 (11-cis and 9-cis) CD63 12q12-q13 CD63 antigen (melanoma 1 antigen) GDF11 12q12 growth differentiation factor 11 CIP29 12q13.13 cytokine induced protein 29 kDa ORMDL2 12q12 ORM1-like 2 (S. cerevisiae) DNAJ 12q13.13 DnaJ protein MMP19 12q14 matrix metalloproteinase 19 PYM 12q13.13 PYM protein DGKA 12q13.3 diacylglycerol kinase, alpha 80kDa SILV 12q13-q14 silver homolog (mouse) CDK2 12q13.3 cyclin-dependent kinase 2 SUOX RAB5B 12q13 RAB5B, member RAS oncogene family ZNFN1A4 12q13 zinc finger protein, subfamily 1A, 4 (Eos) RPS26 12q14 ribosomal protein S26 ERBB3 12q13.3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) PA2G4 12q13 proliferation-associated 2G4, 38kDa RPL41 12q14 ribosomal protein L41 FLJ14451 12q13.13 hypothetical protein FLJ14451 MBC2 12q13.13 hypothetical protein FLJ14451 MLC1SA 12q13.13 hypothetical protein FLJ14451 MYL6 12q12 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle SMARCC2 12q13-q14 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 RNF41 12q13.13 ring finger protein 41 MGC2731 12q13.13 hypothetical protein MGC2731 SLC39A5 12q13.3 solute carrier family 39 (metal ion transporter), member 5 FLJ34236 12q13.13 hypothetical protein FLJ34236 FLJ32452 12q13.13 hypothetical protein FLJ32452 CS 12p11-qter citrate synthase TMEM4 12q15 transmembrane protein 4 USP52 12q13.2-q13.3 ubiquitin specific protease 52
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 699 - 115 - Vladimirov (1996)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunetonsils   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein S26e family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • 40S ribosomal protein S26
  • contribute to pre-rRNA processing (Doherty 2010)
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
  • interact with its pre-mRNA intron I and mRNA fragment (suppresses the splicing of its pre-mRNA)
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA10
    Susceptibility to type 1 diabetes (Schadt 2008)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS