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FLASH GENE
Symbol RPS25 contributors: npt/mct - updated : 02-01-2023
HGNC name ribosomal protein S25
HGNC id 10413
Location 11q23.3      Physical location : 118.886.421 - 118.889.057
Synonym name 40S ribosomal protein S25
Synonym symbol(s) S25
DNA
TYPE functioning gene
STRUCTURE 2.64 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 483 - 125 - 2019 31358992
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
 male systemprostate  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated RiboP
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein S25e family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • structural constituent of ribosome
  • having an essential role for proliferation in all cells (Robledo 2008)
  • essential involvement of RPS25 for hijacking the ribosome
  • at least two alternative translation initiation routes, internal ribosome entry site (IRES) initiation and ribosome shunting, rely on ribosomal protein S25 (RPS25)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • RPS25 interacted with MDM2 and inhibited its E3 ligase activity, resulting in the reduction of MDM2-mediated TP53 ubiquitination and the stabilization and activation of TP53
  • RPS25-MDM2-TP53 regulatory feedback loop, which may have an important role in cancer development and progression
  • in PSMD9 null cells, ribosomal proteins RPS25 and RPL15 fail to localise in the nucleolus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in recurrent pregnancy loss
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerative 
    potential therapeutic target for C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia
    ANIMAL & CELL MODELS