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FLASH GENE
Symbol RPS24 contributors: mct/npt - updated : 07-10-2009
HGNC name ribosomal protein S24
HGNC id 10411
Corresponding disease
DBA3 Diamond-Blackfan anemia 3
Location 10q22.3      Physical location : 79.793.517 - 79.816.570
Synonym name 40S ribosomal protein S24
Synonym symbol(s) DKFZp686N1586
DNA
TYPE functioning gene
STRUCTURE 23.05 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
CDA017 KCNMA1 10q22.3 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 LOC283046 10q22.3 similar to zinc finger protein LOC340780 10q22.3 similar to Inosine-5-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPDH-I) (IMPD 1) DLG5 10q22.3 discs, large (Drosophila) homolog 5 LOC387689 10 LOC387689 RPC155 10q22.3 LOC387689 RPS24 10q22.3 ribosomal protein S24 LOC389980 10 similar to Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylate cyclase-inhibiting G alpha protein) LOC387690 10 LOC387690 LOC387691 10 LOC387691 RAI17 10q23.2 retinoic acid induced 17 PPIF 10q22.3 peptidylprolyl isomerase F (cyclophilin F) FLJ90798 10q23.1 hypothetical protein FLJ90798 LOC338586 10q23.1 similar to XRnf12C LOC143244 10q23.1 similar to eukaryotic initiation factor 5A isoform I variant A LOC389981 10 similar to mannose-binding protein A LOC389982 10 similar to mKIAA1553 protein LOC387692 10 similar to KIAA2020 protein EIF5AP1 10q23.3 eukaryotic translation initiation factor 5A pseudogene 1 LOC389983 10 similar to Gene with similarity to rat kidney-specific (KS) gene SFTPA2 10q22-q23 surfactant, pulmonary-associated protein A2 SFTPA1 10q22.3 surfactant, pulmonary-associated protein A1 LOC389984 10 similar to KIAA1553 protein LOC389985 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC389986 10 similar to bA182L21.1 (novel protein similar to hypothetical proteins) LOC340736 10q23.1 similar to Cathepsin L preproprotein LOC283004 10q23.1 similar to Geranylgeranyl transferase type I beta subunit (Type I protein geranyl-geranyltransferase beta subunit) (GGTase-I-beta) LOC387693 10 similar to BMS1-like, ribosome assembly protein; ribosome biogenesis protein BMS1 homolog; cDNA sequence BC030906; EST AA408648 SFTPD 10q22.3 surfactant, pulmonary-associated protein D
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 671 14.3 130 - Xu (1996)
5 splicing 649 14.6 133 - Xu (1996)
5 - 2820 - 289 - Xu (1996)
7 - 689 - 131 - Xu (1996)
8 - 692 - 132 - Xu (1996)
7 - 674 - 131 - Xu (1996)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunetonsils   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • S24E family of ribosomal proteins
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • encoding a ribosomal protein that is a component of the 40S subunit S24, small subunit
  • required for the assembly of RPS19 into ribosomal subunits, and may assemble into ribosomal subunits in the absence of RPS19, thereby achieving some level of stability
  • having an essential role for proliferation in all cells (Robledo 2008)
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS