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FLASH GENE
Symbol RPS23 contributors: mct - updated : 29-12-2015
HGNC name ribosomal protein S23
HGNC id 10410
Corresponding disease
RPS23D RPS23 deficiency
Location 5q14.2      Physical location : 81.569.140 - 81.574.235
Synonym name 40S ribosomal protein S23,homolog to yeast ribosomal protein S28
DNA
TYPE functioning gene
STRUCTURE 5.09 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 3325 - 143 - 1996 8706699
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text liver in early pregnancy
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , complex
HOMOLOGY
interspecies homolog to yeast S.cerevisiae Tpap1
homolog to C.elegans f28d1.7
Homologene
FAMILY S12P family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic,ribosome
intracellular,nucleus,nucleolus
basic FUNCTION
  • ribosomal protein that is crucial for ribosome function, and that have generated a large number of processed pseudogenes through retroposition
  • serves likely as a conserved “accuracy center”
  • posttranslational prolyl hydroxylation of RPS23 is an evolutionarily conserved modification that regulates translation termination
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • OGFOD1 forms a stable complex with, the hydroxylated RPS23 substrate
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • OGFOD1 catalyzes trans-3 prolyl hydroxylation at Pro62 of the small ribosomal subunit protein uS12 (RPS23)
  • OGFOD1 is a proline hydroxylase of RPS23 for translational termination
  • cell & other
    REGULATION
    Other RPS23 prolyl-3-hydroxylation affects stop codon readthrough in a sequence-specific manner, consistent with the location of the hydroxylation site within the ribosomal decoding center
    ASSOCIATED DISORDERS
    corresponding disease(s) RPS23D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS