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FLASH GENE

Symbol

RPS17

contributors: npt/mct - updated : 07-10-2009

HGNC name	ribosomal protein S17
HGNC id	10397

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DBA4 Diamond-Blackfan anemia 4
Location	15q25.2      Physical location : 82.821.160 - 83.209.208
Synonym name	40S ribosomal protein S17
Synonym symbol(s)	MGC72007, RPS17L1, RPS17L2

DNA

TYPE	functioning gene
STRUCTURE	3.70 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 5 - 511 isoform 1 - 135 - Robledo (2008)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils       highly Reproductive male system prostate     highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

S17E family of ribosomal proteins

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome

basic FUNCTION	ribosomal protein that is a component of the 40S subunit
	having an essential role for proliferation in all cells (Robledo 2008)

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the small 40S ribosomal subunit

INTERACTION

DNA

RNA

binding

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DBA4

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS