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FLASH GENE
Symbol RPS14 contributors: mct - updated : 08-10-2014
HGNC name ribosomal protein S14
HGNC id 10387
Corresponding disease
DEL5QMD acquired 5q-deletion in a subtype of myelodysplastic syndromes
Location 5q33.1      Physical location : 149.823.793 - 149.829.319
Synonym symbol(s) EMTB, PRO2640, S14
DNA
TYPE functioning gene
STRUCTURE 5.56 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 793 - 151 - Ewing (2007)
5 - 787 - 151 - Ewing (2007)
5 - 576 - 151 - Ewing (2007)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunetonsils   highly
Reproductivemale systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY S11P family of ribosomal proteins
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic,ribosome
intracellular,nucleus,nucleolus
basic FUNCTION
  • ribosomal protein that is a component of the 40S subunit
  • plays a key role in erythropoiesis and causes TP53 activation in 5q- syndrome (pMID: 24074450)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the small 40S ribosomal subunit
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • TSPYL2 acts as a novel regulator of RPS14-HDM2-TP53 by regulating the interaction between RPS14 and HDM2 through the control of RPS14 NEDDylation
  • binds to and inactivates MDM2, consequently leading to TP53-dependent cell-cycle arrest and growth inhibition
  • RPS14 negates MYC functions by directly inhibiting its transcriptional activity and mediating its mRNA degradation via miRNA
  • may negatively regulate TP53 activation in acute myeloid leukemia (MDS/AML) cell line
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL5QMD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation deletion   loss of function
    leading to haematopoietic defect characteristic of 5q- syndrome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS