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FLASH GENE

Symbol

RPS14

contributors: mct - updated : 10-01-2023

HGNC name	ribosomal protein S14
HGNC id	10387

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DEL5QMD acquired 5q-deletion in a subtype of myelodysplastic syndromes
Location	5q33.1      Physical location : 149.823.793 - 149.829.319
Synonym name	emetine resistance
	small ribosomal subunit protein uS11
Synonym symbol(s)	EMTB, PRO2640, S14

DNA

TYPE	functioning gene
STRUCTURE	5.56 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001025071 5 - 793 NP_001020242 - 151 - 1992 1549121 NM_001025070 5 - 787 NP_001020241 - 151 - 1992 1549121 NM_005617 5 - 576 NP_005608 - 151 - 1992 1549121

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine parathyroid       highly Lymphoid/Immune tonsils       highly Reproductive male system prostate     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

S11P family of ribosomal proteins

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION	ribosomal protein that is a component of the 40S subunit
	plays a key role in erythropoiesis and causes TP53 activation in 5q- syndrome
	maintains the normal physiological activities of the body by regulating the biosynthesis of ribosomes and the translation of important proteins
	involved in cell proliferation and tumor progression

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the small 40S ribosomal subunit

INTERACTION

DNA

RNA

binding

small molecule

protein	TSPYL2 acts as a novel regulator of RPS14-HDM2-TP53 by regulating the interaction between RPS14 and HDM2 through the control of RPS14 NEDDylation
	binds to and inactivates MDM2, consequently leading to TP53-dependent cell-cycle arrest and growth inhibition
	RPS14 negates MYC functions by directly inhibiting its transcriptional activity and mediating its mRNA degradation via miRNA
	may negatively regulate TP53 activation in acute myeloid leukemia (MDS/AML) cell line
	RPS14 can act as a CDK4/6 inhibitor linking ribosome biogenesis defects to the main engine of cell cycle progression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DEL5QMD

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation deletion   loss of function leading to haematopoietic defect characteristic of 5q- syndrome tumoral     --over   in glioma tumoral     --low   in ER+ breast cancer cells can inhibit their proliferation and metastasis constitutional     --low   significantly reduced in broiler ascites syndrome (BAS)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma may be act as a novel potential therapeutic target for gliomas

ANIMAL & CELL MODELS