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FLASH GENE
Symbol RPS13 contributors: mct - updated : 13-11-2010
HGNC name ribosomal protein S13
HGNC id 10386
Location 11p15.1      Physical location : 17.095.939 - 17.099.220
Synonym name 40S ribosomal protein S13
DNA
TYPE functioning gene
STRUCTURE 3.28 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see NUCB2
regionally located tail to head of PIK3C2A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 529 - 151 - 2005 15680243
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein S15P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • component of the 40S subunit
  • promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis
  • able to specifically bind the fragment and to confer protection against ribonuclease cleavage at sequences near the 5prime and 3prime splice sites
  • could promote the growth and cell cycle progression of gastric cancer cells at least through inhibiting CDKN1B expression
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS