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FLASH GENE
Symbol RPS13 contributors: mct - updated : 13-11-2010
HGNC name ribosomal protein S13
HGNC id 10386
Location 11p15.1      Physical location : 17.095.939 - 17.099.220
Synonym name 40S ribosomal protein S13
DNA
TYPE functioning gene
STRUCTURE 3.28 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map see NUCB2
Physical map
SOX6 11p15.3 SRY (sex determining region Y)-box 6 LOC390095 11 similar to Aldose reductase (AR) (Aldehyde reductase) SMAP 11p15.2 small acidic protein LOC283278 11p15.2 hypothetical protein LOC283278 LOC144100 11p15.2-p15.1 hypothetical protein LOC144100 LOC390096 11 similar to large subunit ribosomal protein L36a OR7E14P 11p15.1 olfactory receptor, family 7, subfamily E, member 14 pseudogene RPS13 11p15.1 ribosomal protein S13 PIK3C2A 11p15.1 phosphoinositide-3-kinase, class 2, alpha polypeptide LOC91561 11p15.1 similar to ribosomal protein S2; 40S ribosomal protein S2 NUCB2 11p15.1-p14 nucleobindin 2 DKFZp686O24166 11p15.1 hypothetical protein DKFZp686O24166 KCNJ11 11p15.1 potassium inwardly-rectifying channel, subfamily J, member 11 ABCC8 11p15.1 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 LOC387757 11 LOC387757 USH1C 11p14.3 Usher syndrome 1C (autosomal recessive, severe) FLJ21290 11p15.1 hypothetical protein FLJ21290 OTOG 11p14.3 otogelin KCNC1 11p15.3 potassium voltage-gated channel, Shaw-related subfamily, member 1 MYOD1 11p15.1 myogenic factor 3 DELGEF 11p14.3 myogenic factor 3 TPH1 11p15.1-p14.3 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) LOC113174 11p15.1 hypothetical protein BC012010 SAA3P 11p15.1-p14.3 serum amyloid A3 pseudogene MRGX3 11p15.1 G protein-coupled receptor MRGX3 MRGX4 11p15.1 G protein-coupled receptor MRGX4 SAA4 11p15.1-p14.3 serum amyloid A4, constitutive SAA2 11p15.1-p14.3 serum amyloid A2 FAM10A5 11p15.1 family with sequence similarity 10, member A5 SAA1 11p15.1-p14.3 serum amyloid A1 HPS5 11p14 Hermansky-Pudlak syndrome 5 GTF2H1 11p15.1-p14 general transcription factor IIH, polypeptide 1, 62kDa
regionally located tail to head of PIK3C2A
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 529 - 151 - 2005 15680243
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Reproductivefemale systembreastmammary gland highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein S15P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • component of the 40S subunit
  • promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis
  • able to specifically bind the fragment and to confer protection against ribonuclease cleavage at sequences near the 5prime and 3prime splice sites
  • could promote the growth and cell cycle progression of gastric cancer cells at least through inhibiting CDKN1B expression
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS