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FLASH GENE
Symbol RPN2 contributors: mct/npt - updated : 09-12-2009
HGNC name ribophorin II
HGNC id 10382
Location 20q11.23      Physical location : 35.807.455 - 35.870.023
Synonym name
  • dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
  • glycosyltransferase 63 kDa subunit
  • Synonym symbol(s) RIBIIR, RPN-II, RPNII, SWP1
    EC.number 2.4.1.119
    DNA
    TYPE functioning gene
    STRUCTURE 62.57 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    C20orf104 20q11.22-q11.23 chromosome 20 open reading frame 104 SCAND1 20q11.1-q11.23 SCAN domain containing 1 C20orf152 20q11.23 chromosome 20 open reading frame 152 HMG4L2 20q11.23 high-mobility group (nonhistone chromosomal) protein 4-like 2 EPB41L1 20q11.2-q12 erythrocyte membrane protein band 4.1-like 1 C20orf4 20pter-q12 chromosome 20 open reading frame 4 DAP4 20q11.23 disks large-associated protein 4 MYL9 20q11.22 myosin, light polypeptide 9, regulatory TGIF2 20q11.2-q12 TGFB-induced factor 2 (TALE family homeobox) C20orf24 20q11.23 chromosome 20 open reading frame 24 SLA2 20q11.22 Src-like-adaptor 2 NDRG3 20q11.21-q11.23 NDRG family member 3 C20orf172 20q11.23 chromosome 20 open reading frame 172 KIAA0889 20q11.23 KIAA0889 protein LOC343574 20q11.23 similar to dJ132F21.2 (Contains a novel protein similar to the L82E from Drosophila) SAMHD1 20q11.22 SAM domain and HD domain 1 RBL1 20q11.21 retinoblastoma-like 1 (p107) RPS3AP3 20q11.2 ribosomal protein S3A pseudogene 3 C20orf132 20q11.22 chromosome 20 open reading frame 132 RPN2 20q11.22-q11.23 ribophorin II GHRH 20q11.21 growth hormone releasing hormone MANBAL 20q11.23-q12 mannosidase, beta A, lysosomal-like SRC 20q11.21 v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) RPL7AL4 20q11.2 ribosomal protein L7A-like 4 BLCAP 20q11.2-q12 bladder cancer associated protein NNAT 20q11.2-q12 neuronatin PPIAP3 20q11.23 peptidylprolyl isomerase A (cyclophilin A) pseudogene 3 GLRXP 20q11.2 glutaredoxin (thioltransferase) pseudogene CTNNBL1 20q11.23-q12 catenin, beta like 1 C20orf102 20q11.23 chromosome 20 open reading frame 102 KIAA0406 20q11.21-q12 Homo sapiens KIAA0406 gene product (KIAA0406), mRNA. C20orf77 20q11.21-q12 chromosome 20 open reading frame 77 TGM2 20q11.2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) KIAA1755 20q12 KIAA1755 protein BPI 20q11.23 bactericidal/permeability-increasing protein LBP 20q11.23-q12 lipopolysaccharide binding protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2490 - 615 - Zmijewski (2009)
    17 - 2538 - 631 - Zmijewski (2009)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinepancreas   highly
     thyroid   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Rpn2
    homolog to yeast S.cerevisiae oligosaccharyl transferase subunit SWP1
    homolog to Drosophila CG6370
    homolog to C.elegans M01A10.3
    Homologene
    FAMILY
  • ribophorin II family
  • SWP1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text type I membrane protein
    basic FUNCTION
  • catalysing the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor onto asparagine acceptor sites within an Asn-X-Ser/Thr consensus motif in newly synthesized proteins
  • required for substrate translocation and gating of the proteolytic channel (Rosenzweig 2008)
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component with RPN1 and DDOST of N-oligosacccharyl transferase
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ADRM1 (interacts with a base subunit RPN2 via its amino-terminus) (Hamazaki 2006)
  • cell & other
    REGULATION
    Other regulated by S-glutathionylation of the regulatory subunit inhibits 26 S proteasomal function (Zmijewski 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS