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FLASH GENE
Symbol RPN2 contributors: mct/npt - updated : 09-12-2009
HGNC name ribophorin II
HGNC id 10382
Location 20q11.23      Physical location : 35.807.455 - 35.870.023
Synonym name
  • dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
  • glycosyltransferase 63 kDa subunit
    • Synonym symbol(s) RIBIIR, RPN-II, RPNII, SWP1
    EC.number 2.4.1.119
    DNA
    TYPE functioning gene
    STRUCTURE 62.57 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2490 - 615 - Zmijewski (2009)
    17 - 2538 - 631 - Zmijewski (2009)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Endocrinepancreas   highly
     thyroid   highly
    Reproductivefemale systemuteruscervix highly
     female systemovary   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Rpn2
    homolog to yeast S.cerevisiae oligosaccharyl transferase subunit SWP1
    homolog to Drosophila CG6370
    homolog to C.elegans M01A10.3
    Homologene
    FAMILY
  • ribophorin II family
  • SWP1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text type I membrane protein
    basic FUNCTION
  • catalysing the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor onto asparagine acceptor sites within an Asn-X-Ser/Thr consensus motif in newly synthesized proteins
  • required for substrate translocation and gating of the proteolytic channel (Rosenzweig 2008)
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component with RPN1 and DDOST of N-oligosacccharyl transferase
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ADRM1 (interacts with a base subunit RPN2 via its amino-terminus) (Hamazaki 2006)
    • cell & other
    REGULATION
    Other regulated by S-glutathionylation of the regulatory subunit inhibits 26 S proteasomal function (Zmijewski 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS