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FLASH GENE

Symbol

RPLP1

contributors: SGE/npt - updated : 11-06-2010

HGNC name	ribosomal protein, large, P1
HGNC id	10372

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q23      Physical location : 69.745.158 - 69.747.884
Synonym name	acidic ribosomal phosphoprotein P1
	60S acidic ribosomal phosphoprotein P1
	60S acidic ribosomal protein P1
Synonym symbol(s)	RPP1, RLA1, P1, MGC5215, FLJ27448, RRP1

DNA

TYPE	functioning gene
STRUCTURE	2.73 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001003 4 - 512 NP_000994 - 114 - Rich (1987) isoform 1 NM_213725 3 - 437 NP_998890 - 89 - Rich (1987) isoform 2

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)

cell lineage
cell lines	Hela cell
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains

conjugated

PhosphoP

mono polymer

pentamer

HOMOLOGY

interspecies	homolog to murine Rplp1 (97.4pc)
	homolog to rattus Rplp1 (98.2pc)

Homologene

FAMILY

ribosomal protein L12P family

CATEGORY

structural protein , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome

basic FUNCTION	playing an important role in the elongation step of protein synthesis
	modulating with P2 the cytoplasmic translation by influencing the interaction between subunits, thereby regulating the rate of cell proliferation (Martinez-Azorin 2008)

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	constituent of ribosome, large subunit (60S subunit)
	can interact with P0 and P2 to form a pentameric complex (P1 and P2 dimers, PO monomer)

INTERACTION

DNA

RNA

binding

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS