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FLASH GENE
Symbol RPLP1 contributors: SGE/npt - updated : 11-06-2010
HGNC name ribosomal protein, large, P1
HGNC id 10372
Location 15q23      Physical location : 69.745.158 - 69.747.884
Synonym name
  • acidic ribosomal phosphoprotein P1
  • 60S acidic ribosomal phosphoprotein P1
  • 60S acidic ribosomal protein P1
    • Synonym symbol(s) RPP1, RLA1, P1, MGC5215, FLJ27448, RRP1
    DNA
    TYPE functioning gene
    STRUCTURE 2.73 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC145853 15q22.31 similar to ENSANGP00000021391 MAP2K5 15q22.2-q22.31 mitogen-activated protein kinase kinase 5 LOC390598 15 similar to RIKEN cDNA C230094B15 LOC388129 15 hypothetical gene supported by BC033162 LOC390599 15 similar to 40S ribosomal protein S15a PIAS1 15q21.3-q22.1 protein inhibitor of activated STAT, 1 MGC4809 15q22.2 serologically defined breast cancer antigen NY-BR-20 CLN6 15q23 ceroid-lipofuscinosis, neuronal 6, late infantile, variant FEM1B 15q22 fem-1 homolog b (C. elegans) ITGA11 15q22.3-q23 integrin, alpha 11 CORO2B 15q22-q23 coronin, actin binding protein, 2B ANP32A 15q22-q23 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A FLJ11722 15q22.31 hypothetical protein FLJ11722 LOC390600 15 similar to RIKEN cDNA 2810413N20 NOX5 15q22.31 NADPH oxidase, EF hand calcium-binding domain 5 SPESP1 15q22.31 sperm equatorial segment protein 1 FLJ33768 15q22.31 hypothetical protein FLJ33768 GLCE 15q22.31 glucuronyl C5-epimerase MPRG 15q22.31 glucuronyl C5-epimerase KIF23 15q22-q23 kinesin family member 23 RPLP1 15q22 ribosomal protein, large, P1 LOC388130 15 LOC388130 LOC388131 15 LOC388131 TLE3 15q22 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) UACA 15q22-q24 uveal autoantigen with coiled-coil domains and ankyrin repeats LOC123397 15q22.32 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) FLJ11196 15q22.32 acheron LOC390601 15 similar to keratin 8, type II cytoskeletal - human THAP10 15q22.32 THAP domain containing 10 FLJ20156 15q22.32 hypothetical protein FLJ20156 LOC283675 15q22.32 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC196993 15q22.32 hypothetical protein LOC196993 LOC390602 15 similar to High mobility group protein 1 (HMG-1) (Amphoterin) (Heparin-binding protein p30) LOC196994 15q22.32 similar to hypothetical protein LOC388132 15 similar to 60S ribosomal protein L17 (L23)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 512 - 114 - Rich (1987)
  • isoform 1
    • 3 - 437 - 89 - Rich (1987)
  • isoform 2
    		•
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines Hela cell
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    mono polymer pentamer
    HOMOLOGY
    interspecies homolog to murine Rplp1 (97.4pc)
    homolog to rattus Rplp1 (98.2pc)
    Homologene
    FAMILY
  • ribosomal protein L12P family
    • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • playing an important role in the elongation step of protein synthesis
  • modulating with P2 the cytoplasmic translation by influencing the interaction between subunits, thereby regulating the rate of cell proliferation (Martinez-Azorin 2008)
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit (60S subunit)
  • can interact with P0 and P2 to form a pentameric complex (P1 and P2 dimers, PO monomer)
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS