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FLASH GENE
Symbol RPLP1 contributors: SGE/npt - updated : 11-06-2010
HGNC name ribosomal protein, large, P1
HGNC id 10372
Location 15q23      Physical location : 69.745.158 - 69.747.884
Synonym name
  • acidic ribosomal phosphoprotein P1
  • 60S acidic ribosomal phosphoprotein P1
  • 60S acidic ribosomal protein P1
  • Synonym symbol(s) RPP1, RLA1, P1, MGC5215, FLJ27448, RRP1
    DNA
    TYPE functioning gene
    STRUCTURE 2.73 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 512 - 114 - Rich (1987)
  • isoform 1
  • 3 - 437 - 89 - Rich (1987)
  • isoform 2
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines Hela cell
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    mono polymer pentamer
    HOMOLOGY
    interspecies homolog to murine Rplp1 (97.4pc)
    homolog to rattus Rplp1 (98.2pc)
    Homologene
    FAMILY
  • ribosomal protein L12P family
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • playing an important role in the elongation step of protein synthesis
  • modulating with P2 the cytoplasmic translation by influencing the interaction between subunits, thereby regulating the rate of cell proliferation (Martinez-Azorin 2008)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit (60S subunit)
  • can interact with P0 and P2 to form a pentameric complex (P1 and P2 dimers, PO monomer)
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS