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FLASH GENE
Symbol RPL7A contributors: - updated : 26-02-2004
HGNC name ribosomal protein L7a
HGNC id 10364
Location 9q34.2      Physical location : 136.215.068 - 136.218.280
Synonym name
  • host gene for intronic RNU36A,B,C small nucleolar RNAs
  • surfeit 3
  • thyroid hormone receptor uncoupling protein
    • Synonym symbol(s) SURF3,TRUP
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, opposite orientation
    text
  • see SURF@
  • RNU24 ,RNU36A,RNU36B,RNU36C embedded in introns 2,4,5 and 6 in opposite orientation and RNU24 (co-transcription)
    • STRUCTURE 3.00 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status confirmed
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Rpl7a
    homolog to Drosophila RpL7A
    homolog to C.elegans Y24D9A.4a
    Homologene
    FAMILY L7AE family of ribosomal proteins
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION inhibiting the ability of a subclass of nuclear hormone receptors including thyroid hormone receptor to transactivate by preventing their binding to their DNA response elements
    CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component ribosomal protein being a component of the 60S subunit
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein binding to a subclass of nuclearhormone receptors including thyroid hormone receptor
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS