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FLASH GENE
Symbol RPL7 contributors: mct/npt - updated : 11-07-2007
HGNC name ribosomal protein L7
HGNC id 10363
Location 8q21.11      Physical location : 74.202.874 - 74.205.869
Synonym name 60S ribosomal protein L7
Synonym symbol(s) humL7-1, MGC117326
DNA
TYPE functioning gene
STRUCTURE 2.30 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC389667 8 similar to tropomyosin 4 SULF1 8q13.1 similar to tropomyosin 4 SLCO5A1 8q13.2 solute carrier family 21 (organic anion transporter), member 15 LOC392230 8 similar to BAG-family molecular chaperone regulator-4 (Silencer of death domains) PRDM14 8p21-p12 PR domain containing 14 LOC346990 8q13.2 similar to H2A histone family, member Z NCOA2 8q13.1 nuclear receptor coactivator 2 LOC392231 8 similar to basic transcription factor 3 TRAM1 8q13.1 translocation associated membrane protein 1 CGI-83 LOC389668 8 similar to hypothetical protein FLJ10307 EYA1 8q13.3 eyes absent homolog 1 (Drosophila) MSC 8q21.1-q21.2 musculin (activated B-cell factor-1) TRPA1 8q13 transient receptor potential cation channel, subfamily A, member 1 LOC392232 8 similar to ankyrin-like protein 1; ankyrin-like with transmembrane domains 1 KCNB2 8q13.2 potassium voltage-gated channel, Shab-related subfamily, member 2 TERF1 8q13 telomeric repeat binding factor (NIMA-interacting) 1 RPESP 8q13.3 RPE-spondin LOC392233 8 similar to Hspcb protein LOC389669 8 LOC389669 RPL7 8q12-q22 ribosomal protein L7 RDH10 8q13.3 retinol dehydrogenase 10 (all-trans) STAU2 8q13-q21.1 staufen, RNA binding protein, homolog 2 (Drosophila) FLJ11011 8q13.3 hypothetical protein FLJ11011 TCEB1 8q13-q21 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) FLJ20533 8q13.3 hypothetical protein FLJ20533 LOC157793 8q13.3 similar to destrin - pig LY96 8q13.3 lymphocyte antigen 96 JPH1 8q21 junctophilin 1 GDAP1 8q13.3-q21 ganglioside-induced differentiation-associated protein 1 LOC286157 8q13.3 similar to mCBP PI15 8q13.3 protease inhibitor 15 LOC83690 8q13.3 CocoaCrisp LOC389670 8 hypothetical gene supported by BC062758 LOC392234 8 similar to Pyruvate kinase, M2 isozyme HNF4G 8q21.3-q22.1 hepatocyte nuclear factor 4, gamma MRPL9P1 8q21.11 mitochondrial ribosomal protein L9 pseudogene ZFH4 8q13.3 mitochondrial ribosomal protein L9 pseudogene PXMP3 8q21.1 peroxisomal membrane protein 3, 35kDa (Zellweger syndrome)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 866 - 248 - Robledo (2008)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 salivary gland   highly
Endocrinepancreas   highly
Hearing/Equilibriumearinnercochlea highly
Lymphoid/Immunetonsils   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone  highly
Epithelialbarrier/lining  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to rattus Rpl7 (96.69 pc)
Homologene
FAMILY
  • ribosomal protein L30P family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • 60S ribosomal protein L7
  • binding to GC-rich structures in 28s rRNA and in mRNAs
  • playing a regulatory role in the translation apparatus ( inhibiting cell-free translation of mRNAs)
  • having an essential role for proliferation in all cells (Robledo 2008)
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS