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FLASH GENE

Symbol

RPL35

contributors: mct - updated : 30-01-2023

HGNC name	ribosomal protein L35
HGNC id	10344

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DBA19 Diamond-Blackfan anemia 19
Location	9q33.3      Physical location : 127.620.157 - 127.624.240
Synonym name	60S ribosomal protein L35
	large ribosomal subunit protein uL29
Synonym symbol(s)	DBA19, L35

DNA

TYPE	functioning gene
STRUCTURE	4.07 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - RPL35 - RPL12 - RPL7A - qter
Authors	Uechi (01)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007209 4 - 452 NP_009140 - 123 - 2019 31690716

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Reproductive male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

ribosomal protein l29p family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleolus

basic FUNCTION	60S ribosomal protein L35, structural constituent of ribosome, involved in protein biosynthesis
	RPL35 function as a positive regulator in aerobic glycolysis

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of ribosome, large subunit

INTERACTION

DNA

RNA

binding

small molecule

protein

RPL35 is the interacting protein of DDX10

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DBA19

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in Neuroblastoma (NB) tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma RPL35/ERK/HIF1A axis could be a potential therapeutic target for the therapy of NB.

ANIMAL & CELL MODELS