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FLASH GENE

Symbol

RPL27

contributors: mct - updated : 23-01-2023

HGNC name	ribosomal protein L27
HGNC id	10328

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DBA16 Diamond-Blackfan anemia 16
Location	17q21.31      Physical location : 41.150.445 - 41.154.965
Genatlas name	60S ribosomal protein L27
Synonym symbol(s)	RL27, DBA16, L27
EC.number	3.6.5.3

DNA

TYPE	functioning gene
STRUCTURE	4.69 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001349921 5 - 595 NP_001336850 - 136 - 2015 25424902 NM_001349922 4 - 782 NP_001336851 - 136 - 2015 25424902 NM_000988 5 - 505 NP_000979 - 136 - 2015 25424902

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive liver         Lymphoid/Immune spleen         Nervous brain         Reproductive male system prostate       Respiratory lung         Urinary kidney

cell lineage
cell lines	Hela cell
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text

kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal KOW motif
	a ribosomal L27E domain

HOMOLOGY

Homologene

FAMILY

L27 E family of ribosomal proteins.

CATEGORY

structural protein , RNA associated

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm
	intracellular,nucleus,nucleolus

basic FUNCTION

structural component of ribosome

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of ribosome,large subunit

INTERACTION

DNA

RNA

binding

small molecule

protein

AGT induced aggregation of RPL27 specifically in proximal tubules, again without apparent change in antiaggregating proteins or the aggresome–autophagosome markers

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DBA16

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS