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FLASH GENE
Symbol RPL26 contributors: mct/npt - updated : 12-02-2016
HGNC name ribosomal protein L26
HGNC id 10327
Location 17p13.1      Physical location : 8.280.833 - 8.286.565
Synonym name 60S ribosomal protein L26
DNA
TYPE functioning gene
STRUCTURE 5.73 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KCNAB3 17p13.1 potassium voltage-gated channel, shaker-related subfamily, beta member 3 TRAPPC1 17p13.1 trafficking protein particle complex 1 LIP8 17p13.2 LYST-interacting protein LIP8 GUCY2D 17p13.1 guanylate cyclase 2D, membrane (retina-specific) ALOX15B 17p13.1 arachidonate 15-lipoxygenase, second type LOC388332 17 similar to Gag protein ALOX12B 17p13.1 arachidonate 12-lipoxygenase, 12R type ALOXE3 17p13.1 arachidonate lipoxygenase 3 HES7 17p13.1 hairy and enhancer of split 7 (Drosophila) PER1 17p13.1-p12 period homolog 1 (Drosophila) VAMP2 17p13.1-p12 vesicle-associated membrane protein 2 (synaptobrevin 2) MGC10744 17p13.1 hypothetical protein MGC10744 FLJ20014 17p13.1 hypothetical protein FLJ20014 AURKB 17p13.1 aurora kinase B FLJ34790 17p13.1 hypothetical protein FLJ34790 FLJ22170 17p13.1 hypothetical protein FLJ22170 PFAS 17p13 phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) RANGNRF 17p13 RAN guanine nucleotide release factor ARHGEF15 17p12 Rho guanine nucleotide exchange factor (GEF) 15 ODF4 17p12 outer dense fiber of sperm tails 4 LOC124751 17p13.1 hypothetical protein LOC124751 RPL26 17p13 ribosomal protein L26 LOC390761 17 similar to RIKEN cDNA 9930039A11 gene NDEL1 17p13.1 nudE nuclear distribution gene E homolog like 1 (A. nidulans) MYH10 17p13.1 myosin, heavy polypeptide 10, non-muscle
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 602 17 145 - 2008 18697920
- - 895 17 145 - 2008 18697920
- - 814 17 145 - 2008 18697920
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Lymphoid/Immunetonsils   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductiveoocyte Mus musculus
cell lineage
cell lines hela cell
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • ribosomal protein L24P family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,ribosome
    text
  • was detected within the nucleolus-like bodys (NLB) of NSN, non-surrounded nucleolus-type oocytes but is virtually absent from NLBs of surrounded nucleolus-type oocytes
  • basic FUNCTION
  • 60S ribosomal protein L26
  • having an essential role for proliferation in all cells (Robledo 2008)
  • RPL26 modulates the HDM2-TP53 interaction by forming a ternary complex among RPL26, HDM2 and TP53, which stabilize TP53 through inhibiting the ubiquitin ligase activity of HDM2
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of ribosome, large subunit
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • MDM2-RPL26 interaction represents an additional important component of the autoregulatory feedback loop that dictates cellular TP53 levels and activity (Ofir-Rosenfeld 2008)
  • RPL26 was characterized as a novel HDM2-interactor
  • overexpression of RPL26 results in activating of TP53, inhibits cell proliferation and induces a TP53-dependent cell cycle arrest
  • RPL26 and NCL interact with each other and with a double-stranded RNA structure in TP53 mRNA to regulate TP53 translation after stress
  • RPL26 likely interacts with NCL and binds to TP53 mRNA in the nucleus
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS