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FLASH GENE

Symbol

RPL15

contributors: mct - updated : 02-01-2023

HGNC name	ribosomal protein L15
HGNC id	10306

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DBA12 Diamond-Blackfan anemia 12
Location	3p24.2      Physical location : 23.958.638 - 23.962.330
Synonym name	60S ribosomal protein L15
Synonym symbol(s)	EC45, RPL10, RPLY10, RPYL10, DBA12, L15, FLJ26304, MGC88603

DNA

TYPE	functioning gene
STRUCTURE	8.09 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

text	transcrpt variants utilizing alternative polyA signals exist

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001253384 5 - 4033 NP_001240313 - 145 - 2001 11223259 NM_001253379 4 - 2743 NP_001240308 - 204 - 2001 11223259 NM_001253380 3 - 2853 NP_001240309 - 204 - 2001 11223259 NM_001253382 4 - 2299 NP_001240311 - 204 - 2001 11223259 NM_001253383 4 - 2221 NP_001240312 - 204 - 2001 11223259 NM_002948 4 - 2155 NP_002939 - 204 - 2001 11223259

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage
cell lines	Hela cell
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer

HOMOLOGY

interspecies	homolog to yeast yl10
	homolog to C.elegans k11h12.2

Homologene

FAMILY

L15 family of ribosomal proteins

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus

basic FUNCTION	60S ribosomal protein L15
	RNA-binding protein dysregulated in various type of cancers
	is required for maintenance of nucleolar structure and formation of pre-60S subunits in the nucleoli

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	constituent of ribosome,large subunit
	component of ribosomal 60S subunit

INTERACTION

DNA

RNA

binding

small molecule

protein

in PSMD9 null cells, ribosomal proteins RPS25 and RPL15 fail to localise in the nucleolus

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DBA12

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   increased metastatic growth in multiple organs and selectively enhanced translation of other ribosomal proteins and cell cycle regulators tumoral     --low   dramatically decreased in pancreatic ductal adenocarcinoma (PDAC) tissues and cell lines tumoral     --over   is remarkably upregulated in human primary colon cancer tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	RPL15 expression status may serve as a reliable prognostic biomarker in PDAC patients
	might be a potential clinical biomarker for colon cancer therapy
Therapy target
	System Type Disorder Pubmed cancer digestive colon target for colon cancer therapy

ANIMAL & CELL MODELS