basic FUNCTION
| playing an important role in 18S rRNA maturation in yeast and in human cells |
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playing a role in regulating c-Myc-enhanced ribosomal biogenesis |
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having an essential role for proliferation in all cells |
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inhibits MYC activity by blocking the recruitment of TRRAP to the promoter regions of MYC target genes |
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inhibiting the binding of TRRAP to the 5S rRNA and tRNA genes |
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RPL5 and RPL11 were required for rRNA export from the nucleolus |
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collaboratively enhances CDKN2A-induced TP53 transcriptional activity and cell cycle arrest |
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unlike other tumor suppressors, RPL5/RPL11 play an essential role in normal cell proliferation, a function cells have evolved to rely on in lieu of a cell cycle checkpoint (pMID: 24061479) |
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RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to MYC mRNA and mediates the degradation of the mRNA, consequently leading to inhibition of MYC activity |
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RPL5, and RPL11 can co-operatively suppress MYC expression, allowing a tightly controlled ribosome biogenesis in cells |
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RPL5 and RPL11 can enhance the transcriptional activity of a TP53 homolog TP73, but through a distinct mechanism |