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FLASH GENE
Symbol RPL11 contributors: mct/pgu - updated : 09-10-2016
HGNC name ribosomal protein L11
HGNC id 10301
Corresponding disease
DBA7 Diamond-Blackfan anemia 7
Location 1p36.11      Physical location : 24.018.293 - 24.022.913
Synonym name
  • 60S ribosomal protein L11
  • CLL-associated antigen KW-
  • cell growth-inhibiting protein 34
  • Synonym symbol(s) GIG34
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 4.65 kb     6 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - RPL22 - RPL11 - RPS8 - RPL5 - RPS27 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 609 - 178 - 2008 19061985
    6 - 641 - 177 - 2008 19061985
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Rpl11 (100.0pc)
    homolog to rattus Rpl11 (100.0pc)
    Homologene
    FAMILY
  • L5P family of ribosomal proteins
  • CATEGORY structural protein , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleolus
    text
  • endogenous, newly synthesized RPL5 and RPL11 continue to be imported into nucleoli even after nucleolar disruption and colocalize with MDM2, TP53, and promyelocytic leukemia protein
  • basic FUNCTION
  • playing an important role in 18S rRNA maturation in yeast and in human cells
  • playing a role in regulating c-Myc-enhanced ribosomal biogenesis
  • having an essential role for proliferation in all cells
  • inhibits MYC activity by blocking the recruitment of TRRAP to the promoter regions of MYC target genes
  • inhibiting the binding of TRRAP to the 5S rRNA and tRNA genes
  • RPL5 and RPL11 were required for rRNA export from the nucleolus
  • collaboratively enhances CDKN2A-induced TP53 transcriptional activity and cell cycle arrest
  • unlike other tumor suppressors, RPL5/RPL11 play an essential role in normal cell proliferation, a function cells have evolved to rely on in lieu of a cell cycle checkpoint (pMID: 24061479)
  • RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to MYC mRNA and mediates the degradation of the mRNA, consequently leading to inhibition of MYC activity
  • RPL5, and RPL11 can co-operatively suppress MYC expression, allowing a tightly controlled ribosome biogenesis in cells
  • RPL5 and RPL11 can enhance the transcriptional activity of a TP53 homolog TP73, but through a distinct mechanism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CDKN2A-MDM2-TP53 and the RPL11-MDM2-TP53 pathways are likely functionally connected
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperates with RPL5, resulting in a robust inhibition of the E3 activity of MDM2, and a stabilization and activation of TP53 approaching that achieved by p14(ARF)
  • NEDD8 is a crucial regulator of RPL11 signalling to TP53
  • NEDDylation of RPL11 plays a critical role in mediating TP53 activation in response to perturbation of ribosomal biogenesis
  • GLTSCR2 binds RPL11, and RPL11 is released from nucleoli in the absence of GLTSCR2
  • specific interaction between RPL11 and the zinc finger of MDM2 via hydrophilic AAs as well as a molecular foundation for better understanding RPL11 inhibition of MDM2 function
  • direct binding to MDM2 E3 ligase and NEDDylation of RPL11 are critical regulators for RPL11 promoter recruitment
  • RPL11 binds to MYC and inhibits its transcriptional activity in response to ribosomal stress
  • induces TP53 following ribosomal stress
  • AKT1S1 negatively regulates the RPL11-HDM2-TP53 nucleolar stress response pathway and suppresses induction of T53-mediated cellular senescence
  • RPL11 and RPL5 activate TP73 by overcoming MDM2 inhibition
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DBA7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS