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FLASH GENE
Symbol RPH3AL contributors: - updated : 26-10-2005
HGNC name rabphilin 3A-like (without C2 domains)
HGNC id 10296
Location 17p13.3      Physical location : 62.181 - 202.633
Synonym symbol(s) NOC2
DNA
TYPE functioning gene
STRUCTURE 34.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC388439 17 LOC388439 LOC390818 17 similar to RPL23AP7 protein SH3GLP3 17q24 SH3-domain GRB2-like pseudogene 3 LOC388443 17 LOC388443 DOC2B 17p13.3 double C2-like domains, beta LOC390820 17 similar to hypothetical protein LOC130888 LOC388435 17 LOC388435 LOC388453 17 LOC388453 LOC388440 17 similar to cytokine LOC388436 17 hypothetical gene supported by BC058012 LOC388444 17 similar to LOC147111 protein LOC388445 17 similar to hypothetical protein BC009233 LOC388446 17 similar to myeloid-associated differentiation marker GCGR 17q25 glucagon receptor LOC388438 17 similar to MEGF11 protein LOC348262 17 hypothetical protein LOC348262 LOC388441 17 similar to aminopeptidase puromycin sensitive; puromycin-sensitive aminopeptidase; metalloproteinase MP100 LOC388437 17 similar to hypothetical protein DKFZp434F142 LOC388447 17 similar to dysferlin-interacting protein 1 LOC390752 17 similar to Buccalin precursor LOC388448 17 similar to prolyl 4-hydroxylase, beta subunit; v-erb-a avian erythroblastic leukemia viral oncogene homolog 2-like; disulfide isomerase; protein disulfide isomerase/oxidoreductase; thyroid hormone-binding protein p55; glutathione-in RPH3AL 17p13.3 rabphilin 3A-like (without C2 domains) KPNA2 17q23.1-q23.3 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) LOC390819 17 similar to aminopeptidase puromycin sensitive; puromycin-sensitive aminopeptidase; metalloproteinase MP100 LOC388442 17 similar to TBC1 domain family member 3 (Rab GTPase-activating protein PRC17) (Prostate cancer gene 17 protein) (TRE17 alpha protein) LOC388449 17 LOC388449 LOC388450 17 similar to Ethanolamine-phosphate cytidylyltransferase (Phosphorylethanolamine transferase) (CTP:phosphoethanolamine cytidylyltransferase) LOC388451 17 hypothetical gene supported by AL137626; NM_016538 LOC388452 17 hypothetical gene supported by BC012327; NM_002359
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
 stomach    
Endocrinepancreas    
 thyroid    
Reproductivefemale systemovary   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • putative zinc finger protein motif
  • a conserved Rab3-binding domain (RBD3)
  • HOMOLOGY
    interspecies homolog to rattus Rph3al
    Homologene
    FAMILY
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytoskeleton
    text cytoskeletal protein binding protein
    basic FUNCTION
  • involved in regulated endocrine exocytosis
  • involved in the recruitment of secretory granules at the plasma membrane possibly via the interaction with UNC13B
  • functioning as a potential RAB3B effector protein in epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein cytoskeletal protein binding protein(cytoskeleton LIM domain-containing protein zyxin)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS