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FLASH GENE
Symbol RPAIN contributors: mct - updated : 05-05-2020
HGNC name RPA interacting protein
HGNC id 28641
Location 17p13.2      Physical location : 5.322.960 - 5.336.340
Synonym name RAP interaction protein
Synonym symbol(s) RIP, HRIP, MGC4189, FLJ25625, FLJ30490, FLJ42429, hRIPalpha
DNA
TYPE functioning gene
STRUCTURE 13.38 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1536 - 739 - 2005 16008515
5 - 1474 - 148 - 2005 16008515
  • variant gamma1
  • lost the C-terminal Zn-finger-like structure
  • 6 - 1538 - 172 - 2005 16008515
  • variant beta
  • deletes one Zn-finger-like structure
  • plays an important role in replication protein A (RPA) deposition in promyelocytic leukemia nuclear bodies and thereby supplements RPA for DNA metabolism
  • - - 1698 - 143 - 2005 16008515
    lost the C-terminal Zn-finger-like structure
    - - 1548 - 142 - 2005 16008515
    lost the C-terminal Zn-finger-like structure
    - - 1283 - 101 - 2005 16008515
    only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region
    4 - 1362 - 106 - 2005 16008515
  • variant delta 2
  • only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region
  • - - 1219 - 106 - 2005 16008515
    only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region
    - - 1424 - 107 - 2005 16008515
    only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region
    7 - 1679 - 219 - 2005 16008515
    6 - 2654 - 231 - 2005 16008515
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   highly
    Nervousnervecranial nerve  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal arginine-rich basic region
  • a RIP-type zinc finger
  • an acidic region and two C-terminal Zn finger-like structures
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    basic FUNCTION
  • mediating the import of RPA complex into the nucleus, possibly via some interaction with importin beta
  • might be involved in the basic cell function, and plays a role in the alternative nuclear ingress
  • is involved in cell proliferation through regulation of RPA1 transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the RPA1 subunit of RPA complex
  • is the nuclear transporter of RPA1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    may contribute to the development of preeclampsia through regulating trophoblast invasion and apoptosis via C1Q
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential diagnostic target for preeclampsia
  • Therapy target
    SystemTypeDisorderPubmed
    reproductionpregnancy 
    potential therapeutic target for preeclampsia
    ANIMAL & CELL MODELS