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FLASH GENE
Symbol RPAIN contributors: - updated : 04-04-2007
HGNC name RPA interacting protein
HGNC id 28641
Location 17p13.2      Physical location : 5.322.960 - 5.336.340
Synonym name RAP interaction protein
Synonym symbol(s) RIP, HRIP, MGC4189
DNA
TYPE functioning gene
STRUCTURE 13.00 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1536 - 739 - Chen
- - 1472 - 145 - Chen
lost the C-terminal Zn-finger-like structure
- - 1395 - 172 - Chen
  • deletes one Zn-finger-like structure
  • plays an important role in replication protein A (RPA) deposition in promyelocytic leukemia nuclear bodies and thereby supplements RPA for DNA metabolism
  • - - 1698 - 143 - Chen
    lost the C-terminal Zn-finger-like structure
    - - 1548 - 142 - Chen
    lost the C-terminal Zn-finger-like structure
    - - 1283 - 101 - Chen
    only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region
    - - 1360 - 106 - Chen
    only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region
    - - 1219 - 106 - Chen
    only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region
    - - 1424 - 107 - Chen
    only contain the N-terminal arginine-rich basic region and the core sequence of the acidic region
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   highly
    Nervousnervecranial nerve  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal arginine-rich basic region
  • a RIP-type zinc finger
  • an acidic region and two C-terminal Zn finger-like structures
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • mediating the import of RPA complex into the nucleus, possibly via some interaction with importin beta
  • might be involved in the basic cell function, and plays a role in the alternative nuclear ingress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the RPA1 subunit of RPA complex
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS