basic FUNCTION
| colocalizing with RAD51 on synapsed axes in meiosis and facilitating RAD51 function, also colocalizing with BLM in meiotic prophase nuclei of spermatocytes |
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RPA2 phosphorylation facilitates chromosomal DNA repair |
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its hyperphosphorylation plays a critical role in maintenance of genomic stability and cell survival after a DNA replication block via promotion of homologous recombination |
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is an exchange point for multiple proteins involved in DNA repair, homologous recombination, and checkpoint processes and that it binds to different partners with comparable binding affinity using a single site |
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with RPA1, and RPA3, plays essential roles in DNA transactions |
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RPA1 and RPA2 are arranged from 5prime to 3prime along the unfolded telomeric G4, as already described for unstructured single-stranded DNA |