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FLASH GENE

Symbol

ROS1

contributors: - updated : 17-11-2005

HGNC name	v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
HGNC id	10261

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q21-q22      Physical location : 117.609.529 - 117.747.018
Synonym name	proto-oncogene tyrosine-protein kinase ROS
Synonym symbol(s)	ROS, MCF3
EC.number	2.7.1.112

DNA

TYPE	functioning gene
STRUCTURE	39.00 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed gp280ROS1 - - 8300 280 - - Sharma 116ROS1 - - 4000 - 116 - Sharma containing the entire tyrosine kinase domain and two amino acids of the transmembrane domain variant 1 - - 7368 264 2347 - Birchmeier maybe the same than gp280ROS1

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Respiratory lung

cell lineage
cell lines	variety of tumor cell lines highly
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a tyrosine kinase domain
	a transmembrane domain
	an extracellular domain carrying an N glycosylation site

conjugated

GlycoP , PhosphoP

HOMOLOGY

interspecies	homolog to avian UR2 sarcoma virus oncogene (v-ros)
	homolog to murine Ros1
	homolog to Drosophila sev
	homolog to C.elegans R151.4

Homologene

FAMILY

sevenless subfamily of tyrosine kinase insulin receptor genes

CATEGORY

enzyme , protooncogene , receptor membrane tyrosine kinase

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I integral membrane protein

basic FUNCTION

receptor tyrosine kinase,class II, functioning as a growth or differentiation factor receptor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	sodium/potassium-transporting ATPase

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to myocardial infarction

Variant & Polymorphism SNP	increasing the risk of myocardial infarction

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS