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FLASH GENE
Symbol ROS1 contributors: - updated : 17-11-2005
HGNC name v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
HGNC id 10261
Location 6q21-q22      Physical location : 117.609.529 - 117.747.018
Synonym name proto-oncogene tyrosine-protein kinase ROS
Synonym symbol(s) ROS, MCF3
EC.number 2.7.1.112
DNA
TYPE functioning gene
STRUCTURE 39.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
NT5C2L1 6q22.31 5'-nucleotidase, cytosolic II-like 1 COL10A1 6q21-q22.3 collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) TSPYL4 6q22.31 TSPY-like 4 RPS5P1 6q22.1-q22.3 ribosomal protein S5 pseudogene 1 TSPYL 6q21-q23 TSPY-like SART2 6q22 squamous cell carcinoma antigen recognized by T cells 2 LOC391964 6 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) C6orf187 6q22.31 chromosome 6 open reading frame 187 C6orf188 6q22.31 chromosome 6 open reading frame 188 C6orf78 6q22.31 chromosome 6 open reading frame 78 RWDD1 6q13-q22.33 RWD domain containing 1 RSHL3 6q22.31 radial spokehead-like 3 C6orf113 6q22.31 chromosome 6 open reading frame 113 KPNA5 6q22.31 karyopherin alpha 5 (importin alpha 6) C6orf189 6q22.31 chromosome 6 open reading frame 189 GPRC6A 6q22.31 G protein-coupled receptor, family C, group 6, member A RFXDC1 6q22.31 regulatory factor X domain containing 1 VGLL2 6q22.31 vestigial like 2 (Drosophila) ROS1 6q21-q22 v-ros UR2 sarcoma virus oncogene homolog 1 (avian) DCBLD1 6q22.31 discoidin, CUB and LCCL domain containing 1 GOPC 6q21 golgi associated PDZ and coiled-coil motif containing LOC221308 6q22.31 similar to RIKEN cDNA 5730521E12 C6orf68 6q22.31 chromosome 6 open reading frame 68 SLC35F1 6q22.31 solute carrier family 35, member F1 LOC391965 6 hypothetical gene supported by BX647084
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 8300 280 - - Sharma
- - 4000 - 116 - Sharma
containing the entire tyrosine kinase domain and two amino acids of the transmembrane domain
- - 7368 264 2347 - Birchmeier
maybe the same than gp280ROS1
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
cell lineage
cell lines variety of tumor cell lines highly
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a tyrosine kinase domain
  • a transmembrane domain
  • an extracellular domain carrying an N glycosylation site
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to avian UR2 sarcoma virus oncogene (v-ros)
    homolog to murine Ros1
    homolog to Drosophila sev
    homolog to C.elegans R151.4
    Homologene
    FAMILY sevenless subfamily of tyrosine kinase insulin receptor genes
    CATEGORY enzyme , protooncogene , receptor membrane tyrosine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I integral membrane protein
    basic FUNCTION
  • receptor tyrosine kinase,class II, functioning as a growth or differentiation factor receptor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text sodium/potassium-transporting ATPase
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to myocardial infarction
    Variant & Polymorphism SNP increasing the risk of myocardial infarction
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS