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FLASH GENE
Symbol ROR1 contributors: mct - updated : 24-06-2011
HGNC name receptor tyrosine kinase-like orphan receptor 1
HGNC id 10256
Location 1p31.3      Physical location : 64.239.689 - 64.644.707
Synonym name neutrophic tyrosine kinase,receptor-related 1
Synonym symbol(s) NTRKR1
EC.number 2.7.1.112/ 2.7.10.1
DNA
TYPE functioning gene
STRUCTURE 405.02 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3382 - 937 - 1996 8875995
7 - 2303 - 393 - 1996 8875995
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  lowly Homo sapiens
cell lineage
cell lines B-CLL and mantle cell lymphoma
fluid/secretion
at STAGE
physiological period embryo
Text
  • in all tissues, highly, and lens epithelium, in hippocampal neurons during synapse formation
  • expressed in undifferentiated embryonic stem cells, but not in major adult tissues and at an early stage of B-cell development
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ligand binding ectodomain
  • a single transmembrane segment and a cytoplasmic C terminal tail with intrinsic threonine kinase activity
  • one frizzled domain (FZ)
  • one Ig-like C2 type domain, a cysteine-rich kringle domain
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to tyrosine kinase domain of growth factor-receptors (TRK),strongly
    homolog to ROR2
    Homologene
    FAMILY Ror-family receptor tyrosine kinases
    CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text integral plasma membrane
    basic FUNCTION
  • acts in part redundantly with ROR2 in the skeletal and cardiovascular systems
  • play crucial roles in the development of various organs and tissues
  • ROR1, and ROR2, play a key role in WNT-5A-activated signaling pathways leading to synapse formation in the mammalian CNS
  • might play a role during early stages of development in central neurons
  • receptor protein tyrosine kinase that modulates neurite growth in the central nervous system
  • general role of ROR1 in lymphoma genesis and/or maintenance
  • ROR1 and FMOD may be involved in the survival of CLL cells
  • embryonic glycoprotein involved in several developmental processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STAT3 binds to the ROR1 promoter and activates ROR1 in CLL cells in chronic lymphocytic leukemia
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in blood cells might assist in early detection of renal malignancies, providing taking into consideration the clinical symptoms of the disease
    tumoral     --over  
    in B-cell chronic lymphocytic leukemia (B-CLL), but not normal B cell
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be used as a diagnostic marker for CLL, and because can exclusively be detected on neoplastic B cells, it may greatly increase both, specificity as well as sensitivity, in lymphoma diagnostics
    • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    T-cell therapies targeting ROR1 may be effective in B-CLL and other ROR1-positive tumors
    ANIMAL & CELL MODELS
  • Ror1 mutant mice display a postnatal growth retardation phenotype