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FLASH GENE
Symbol ROR1 contributors: mct - updated : 24-06-2011
HGNC name receptor tyrosine kinase-like orphan receptor 1
HGNC id 10256
Location 1p31.3      Physical location : 64.239.689 - 64.644.707
Synonym name neutrophic tyrosine kinase,receptor-related 1
Synonym symbol(s) NTRKR1
EC.number 2.7.1.112/ 2.7.10.1
DNA
TYPE functioning gene
STRUCTURE 405.02 kb     9 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
CYP2J2 1p31.3-p31.2 cytochrome P450, family 2, subfamily J, polypeptide 2 MGC34837 1p32.1 hypothetical protein MGC34837 NFIA 1p31.3-p31.2 nuclear factor I/A BBP 1p32.1 beta-amyloid binding protein precursor INADL 1p32.1-p31.3 beta-amyloid binding protein precursor FLJ10884 1p32.1 hypothetical protein FLJ10884 LOC388637 1 similar to LOC163782 protein USP1 1p32.1-p31.3 ubiquitin specific protease 1 ANGPTL3 1p31 angiopoietin-like 3 AUTL1 1p31.3 AUT-like 1, cysteine endopeptidase (S. cerevisiae) LOC199897 1p32.1 hypothetical LOC199897 LOC388638 1 LOC388638 FOXD3 1p32-p31 forkhead box D3 ALG6 1p31.3 forkhead box D3 ITGB3BP 1p31.3 integrin beta 3 binding protein (beta3-endonexin) KIAA1799 1p31.3 KIAA1799 protein PGM1 1p22.3 phosphoglucomutase 1 ROR1 1p32-p31 receptor tyrosine kinase-like orphan receptor 1 MGC35130 1p31.3 hypothetical protein MGC35130 KIAA1573 1p31.3 KIAA1573 protein KIAA1579 1p31.3 hypothetical protein FLJ10770 JAK1 1p31.3 Janus kinase 1 (a protein tyrosine kinase) LOC391045 1 similar to Solute carrier family 2, facilitated glucose transporter, member 3 (Glucose transporter type 3, brain) MRPS21P1 1p31.3 mitochondrial ribosomal protein S21 pseudogene AK3 1p31 adenylate kinase 3 DNAJC6 1pter-q31.3 DnaJ (Hsp40) homolog, subfamily C, member 6 LEPR 1p31 leptin receptor PDE4B 1p31 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) DKFZp761D221 1p31.3 hypothetical protein DKFZp761D221 FLJ40873 1p31.3 hypothetical protein FLJ40873 INSL5 1p31.1-p22.3 insulin-like 5 FLJ23129 1p31.3 hypothetical protein FLJ23129 MI-ER1 1p31.3 mesoderm induction early response 1 SLC35D1 1p32-p31 solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 IL23R 1p31.3-p31.2 interleukin-23 receptor IL12RB2 1p31.3-p31.2 interleukin 12 receptor, beta 2 PAI-RBP1 1p31-p22 PAI-1 mRNA-binding protein LOC391046 1 similar to heterogeneous nuclear ribonucleoprotein C isoform b; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3382 - 937 - 1996 8875995
7 - 2303 - 393 - 1996 8875995
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  lowly Homo sapiens
cell lineage
cell lines B-CLL and mantle cell lymphoma
fluid/secretion
at STAGE
physiological period embryo
Text
  • in all tissues, highly, and lens epithelium, in hippocampal neurons during synapse formation
  • expressed in undifferentiated embryonic stem cells, but not in major adult tissues and at an early stage of B-cell development
    • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ligand binding ectodomain
  • a single transmembrane segment and a cytoplasmic C terminal tail with intrinsic threonine kinase activity
  • one frizzled domain (FZ)
  • one Ig-like C2 type domain, a cysteine-rich kringle domain
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to tyrosine kinase domain of growth factor-receptors (TRK),strongly
    homolog to ROR2
    Homologene
    FAMILY Ror-family receptor tyrosine kinases
    CATEGORY enzyme , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text integral plasma membrane
    basic FUNCTION
  • acts in part redundantly with ROR2 in the skeletal and cardiovascular systems
  • play crucial roles in the development of various organs and tissues
  • ROR1, and ROR2, play a key role in WNT-5A-activated signaling pathways leading to synapse formation in the mammalian CNS
  • might play a role during early stages of development in central neurons
  • receptor protein tyrosine kinase that modulates neurite growth in the central nervous system
  • general role of ROR1 in lymphoma genesis and/or maintenance
  • ROR1 and FMOD may be involved in the survival of CLL cells
  • embryonic glycoprotein involved in several developmental processes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • STAT3 binds to the ROR1 promoter and activates ROR1 in CLL cells in chronic lymphocytic leukemia
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in blood cells might assist in early detection of renal malignancies, providing taking into consideration the clinical symptoms of the disease
    tumoral     --over  
    in B-cell chronic lymphocytic leukemia (B-CLL), but not normal B cell
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be used as a diagnostic marker for CLL, and because can exclusively be detected on neoplastic B cells, it may greatly increase both, specificity as well as sensitivity, in lymphoma diagnostics
    • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    T-cell therapies targeting ROR1 may be effective in B-CLL and other ROR1-positive tumors
    ANIMAL & CELL MODELS
  • Ror1 mutant mice display a postnatal growth retardation phenotype