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FLASH GENE
Symbol ROPN1 contributors: npt/ - updated : 05-08-2004
HGNC name ropporin, rhophilin associated protein 1
HGNC id 17692
Location 3q21.1      Physical location : 123.687.880 - 123.710.199
Synonym name
  • ropporin-1A
  • outer dense fiber of sperm tails 6
  • AKAP-binding sperm protein ropporin
  • cancer/testis antigen 91
  • Synonym symbol(s) ODF6, ropporin, RHPNAP1, CT91, ROPN1A
    DNA
    TYPE functioning gene
    STRUCTURE 22.32 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MGC50831 3q21.1 hypothetical protein MGC50831 CD86 3q21 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) CASR 3q21-q24 calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) LOC391570 3 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) CSTA 3q21 cystatin A (stefin A) LOC131076 3q21.1 hypothetical LOC131076 E2IG5 3q21.1 growth and transformation-dependent protein WDR5B 3q21.1 WD repeat domain 5B KPNA1 3q21 karyopherin alpha 1 (importin alpha 5) BAL 3q13-q21 B aggressive lymphoma gene LOC151636 FLJ40597 3q21.1 hypothetical protein FLJ40597 LOC339881 3q21.1 similar to eukaryotic initiation factor 4B KIAA1268 3q21.1 KIAA1268 protein HSPBAP1 3q21 HSPB (heat shock 27kDa) associated protein 1 DIRC2 3q21.1 disrupted in renal carcinoma 2 SEMA5B 3q21.1 sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B PDIR 3q21.1 for protein disulfide isomerase-related SEC22L2 3q21.1 SEC22 vesicle trafficking protein-like 2 (S. cerevisiae) ADCY5 3q13.2-q21 adenylate cyclase 5 PTPLB 3q21.1 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b MYLK 3q21 myosin, light polypeptide kinase FLJ12892 3q21.2 hypothetical protein FLJ12892 ROPN1 3q21.2 ropporin, rhophilin associated protein 1 HAPIP q21.1-q21.2 huntingtin-associated protein interacting protein (duo) TRAD 3q21.2 serine/threonine kinase with Dbl- and pleckstrin homology domains UMPS 3q13 uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) ITGB5 3q21.2 integrin, beta 5 MUC13 3q13.3 mucin 13, epithelial transmembrane HEG 3q21.2 HEG homolog SLC12A8 3q21 solute carrier family 12 (potassium/chloride transporters), member 8 ZNF148 3q21 zinc finger protein 148 (pHZ-52) SNX4 3q21.1-q21.3 sorting nexin 4 OSBPL11 3q21 oxysterol binding protein-like 11 LOC389144 3 similar to seven transmembrane helix receptor OR7E93P 3q13.33 olfactory receptor, family 7, subfamily E, member 93 pseudogene OR7E53P 3q13.33 olfactory receptor, family 7, subfamily E, member 53 pseudogene OR7E97P 3q13.33 olfactory receptor, family 7, subfamily E, member 97 pseudogene LOC344729 3q21.2 similar to chromosome 11 open reading frame2; chromosome  11 open reading frame2 LOC389145 3 LOC389145 LOC165622 3q21.2 similar to Alkaline sphingomyelinase LOC200810 3q21.2 similar to asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase); beta-1,4 mannosyltransferase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1112 - 212 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivesperm cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • ropporin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    text in the principal piece and the end piece of sperm flagella
    basic FUNCTION
  • cAMP-dependent protein kinase regulator activity
  • porin activity
  • have a role in the fusion of sperm to egg plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AKAP3
  • binding to rhophilin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS