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FLASH GENE
Symbol ROMO1 contributors: mct - updated : 21-03-3012
HGNC name reactive oxygen species modulator 1
HGNC id 16185
Location 20q11.23      Physical location : 34.287.231 - 34.288.901
Synonym name
  • homolog of mouse RIKEN 2010100O12 gene
  • chromosome 20 open reading frame 52
  • mitochondrial targeting GXXXG protein
  • glyrichin
  • Synonym symbol(s) bA353C18.2, C20orf52, MTGMP, MGC111180
    DNA
    TYPE functioning gene
    STRUCTURE 1.67 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 477 8 79 - 2008 18313394
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • transmembrane domain
  • HOMOLOGY
    interspecies homolog to murine RIKEN 2010100O12
    Homologene
    FAMILY
  • MGR2 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text
  • localized in the mitochondria 2)
  • basic FUNCTION
  • may play an important role in redox signaling in cancer cells
  • integral mitochondrial inner-membrane protein that coordinately regulates mitochondrial morphology and cell proliferation
  • ROMO1-derived ROS play potentially an important role in apoptotic cell death triggered by withdrawal of cell survival factors
  • recruits BCL2L1 to reduce the mitochondrial membrane potential, resulting in ROS production and apoptotic cell death
  • molecular bridge between TNF-alpha signaling and the mitochondria for ROS production that triggers TNF-alpha-mediated apoptosis, as well as a novel target in the development of anti-inflammatory agents that block the origin of ROS production
  • subsequently triggers SKP2-mediated ubiquitylation and degradation of MYC
  • is responsible for a serum deprivation-induced increase in reactive oxygen species (ROS)
  • involved in generation of reactive oxygen species in mitochondria
  • localized in the mitochondria and mediates mitochondrial ROS production through complex III of the mitochondrial electron transport chain
  • mediates mitochondrial ROS production and apoptosis induced by oxidative stress in lung epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ROMO1 and B-cell lymphoma-extra large (BCL2L1) are directly associated with TNF-alpha-induced ROS production
  • cell & other
    REGULATION
    induced by upregulated MYC protein, which triggers the G1-S phase progression in response to growth-stimulatory signals, induces reactive oxygen species modulator 1 (ROMO1) expression
    oxidative stress playing an important role in oxidative stress-induced mitochondrial ROS production and
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in brain tumor cell lines and tumor tissues
    constitutional     --over  
    results in mitochondrial fragmentation and release of mitochondrial Smac/Diablo to the cytosol with no effect on apoptosis
    constitutional     --over  
    correlates with epithelial cell death in patients with idiopathic pulmonary fibrosis (IPF)
    tumoral     --over  
    in a variety of cancer cell lines and inhepatocellular carcinoma tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS