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FLASH GENE
Symbol ROGDI contributors: mct - updated : 04-04-2012
HGNC name rogdi homolog
HGNC id 29478
Corresponding disease
KSTS Kohlschutter-Tonz syndrome
Location 16p13.3      Physical location : 4.846.969 - 4.852.674
Synonym name
  • leucine zipper domain protein
    • Synonym symbol(s) FLJ22386
    DNA
    TYPE functioning gene
    STRUCTURE 5.70 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1474 - 287 - 2012 22424600
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Nervousbrain   highly Homo sapiens
     spinal cord     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • most conserved domain of the protein is the C terminus (AAs 253–281)
    • HOMOLOGY
    interspecies ortholog to drosophila Rogdi
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nuclear envelope
    text
  • localizes to the nuclear envelope
    • basic FUNCTION
  • plays an important role in neuronal development as well as amelogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with a protein called disrupted in schizophrenia 1 (DISC1)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) KSTS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS