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FLASH GENE
Symbol RNLS contributors: mct/npt - updated : 11-09-2009
HGNC name renalase, FAD-dependent amine oxidase
HGNC id 25641
Location 10q23.31      Physical location : 90.033.620 - 90.343.082
Synonym name
  • renalase
  • chromosome 10 open reading frame 59
  • Synonym symbol(s) FLJ11218, C10orf59
    EC.number 1.4.-.-
    DNA
    TYPE functioning gene
    STRUCTURE 309.39 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2420 37 342 - Zhao (2007)
    8 - 2180 - 315 - Zhao (2007)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinesmall intestine   
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • reverse transcriptase domain
  • HOMOLOGY
    Homologene
    FAMILY
  • renalase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a role of amine oxidase that is secreted by the kidney, circulating in blood, and modulating cardiac function and systemic blood pressure
  • secreted by the kidney, circulates in blood, and modulates cardiac function and systemic blood pressure (Xu 2005)
  • secreted amine oxidase that metabolizes catecholamines (Xu 2007)
  • may well have important cardiovascular functions, but there is no proof that its actions are mediated through catecholamine-metabolising activity (Boomsma 2007)
  • plays a key role in the regulation of sympathetic tone, blood pressure and cardiac function (Desir 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    renalase pathway is a previously unrecognized mechanism for regulating circulating catecholamines, and, therefore, cardiac function, and blood pressure (Xu 2007)
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in patients with chronic kidney disease and end-stage renal disease (Desir 2008)
    Susceptibility to essential hypertension (EH)
    Variant & Polymorphism SNP three SNPs, rs2576178, rs2296545, and rs2114406, showed significant associations with EH (Zhao 2007)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Rats subjected to subtotal nephrectomy develop hypertension and chronic kidney disease, and exhibit low plasma and cardiac renalase, and abnormal renalase activation (Desir 2008)