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FLASH GENE

Symbol

RNH1

contributors: - updated : 13-12-2006

HGNC name	ribonuclease/angiogenin inhibitor 1
HGNC id	10074

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.5      Physical location : 494.511 - 507.273
Synonym name	placental ribonuclease inhibitor
Synonym symbol(s)	RNH, RAI

DNA

TYPE	functioning gene
STRUCTURE	12.00 kb     10 Exon(s)

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see INS , PTH PTH

regionally located

distal to IGF2

RNA

TRANSCRIPTS	type	messenger

text	all variants encode the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2057 - 461 - Iyer variant 2 - - 1989 - 461 - Iyer variant 3 - - 1816 - 461 - Iyer variant 4 - - 1884 - 461 - Iyer variant 5 - - 1937 - 461 - Iyer variant 6 - - 2005 - 461 - Iyer variant 7 - - 1764 - 461 - Iyer variant 8 - - 1832 - 461 - Iyer

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     moderately   intestine large intestine colon   moderately   liver       moderately   pancreas exocrine       moderately Lymphoid/Immune lymph node       moderately Nervous brain       highly Reproductive female system uterus cervix   highly   female system placenta     highly   female system ovary     moderately   male system testis     moderately   male system prostate     moderately Skin/Tegument skin       highly Urinary kidney       moderately Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES		acid
STRUCTURE

motifs/domains

fifteen LRR (leucine-rich) repeats

HOMOLOGY

interspecies	ortholog to murine Rnh1
	ortholog to rattus Rnh1
	ortholog to chimpanzee rnh

Homologene

FAMILY

family of proteinaceous cytoplasmic RNase inhibitors

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	acting as an inhibitor of pancreatic RNase and angiogenin
	may also function in the modulation of cellular activities
	may be essential for control of mRNA turnover

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

nucleic

signaling

RNA catabolism

a component

forming a tight one-to-one complex with the RNase

INTERACTION

DNA

RNA

binding

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS