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FLASH GENE
Symbol RNH1 contributors: - updated : 13-12-2006
HGNC name ribonuclease/angiogenin inhibitor 1
HGNC id 10074
Location 11p15.5      Physical location : 494.511 - 507.273
Synonym name
  • placental ribonuclease inhibitor
  • Synonym symbol(s) RNH, RAI
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     10 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map see INS , PTH PTH
    regionally located distal to IGF2
    RNA
    TRANSCRIPTS type messenger
    text
  • all variants encode the same protein
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2057 - 461 - Iyer
    - - 1989 - 461 - Iyer
    - - 1816 - 461 - Iyer
    - - 1884 - 461 - Iyer
    - - 1937 - 461 - Iyer
    - - 2005 - 461 - Iyer
    - - 1764 - 461 - Iyer
    - - 1832 - 461 - Iyer
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
     intestinelarge intestinecolon moderately
     liver   moderately
     pancreas exocrine   moderately
    Lymphoid/Immunelymph node   moderately
    Nervousbrain   highly
    Reproductivefemale systemuteruscervix highly
     female systemplacenta  highly
     female systemovary  moderately
     male systemtestis  moderately
     male systemprostate  moderately
    Skin/Tegumentskin   highly
    Urinarykidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • fifteen LRR (leucine-rich) repeats
  • HOMOLOGY
    interspecies ortholog to murine Rnh1
    ortholog to rattus Rnh1
    ortholog to chimpanzee rnh
    Homologene
    FAMILY
  • family of proteinaceous cytoplasmic RNase inhibitors
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as an inhibitor of pancreatic RNase and angiogenin
  • may also function in the modulation of cellular activities
  • may be essential for control of mRNA turnover
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • RNA catabolism
  • a component
  • forming a tight one-to-one complex with the RNase
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS