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FLASH GENE
Symbol RNF7 contributors: mct/npt - updated : 10-06-2020
HGNC name ring finger protein 7
HGNC id 10070
Location 3q23      Physical location : 141.457.050 - 141.465.242
Synonym name
  • sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
  • zinc RING finger protein SAG
  • CKII beta-binding protein 1
  • Sensitive to Apoptosis Gene
  • Synonym symbol(s) CKBBP1, ROC2, SAG, RBX2
    DNA
    TYPE functioning gene
    STRUCTURE 9.35 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1609 - 90 - 2017 29194363
    3 - 1599 - 113 - 2017 29194363
    2 - 1962 - 97 - 2017 29194363
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SKP1/cullin/F box domain
  • zinc RING finger domain at the C terminus
  • conjugated PhosphoP , MetalloP
    HOMOLOGY
    interspecies homolog to murine Rnf7
    intraspecies homolog to APC11 (ANAPC11)
    Homologene
    FAMILY
  • SKP1-cullin F box protein (SCF) E3 ubiquitin ligase family
  • RING-box family (RBX) family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • mainly localized in nucleus and lightly in cytoplasm (He 2007)
  • basic FUNCTION
  • protective molecule,acting as an antioxidant to inhibit apoptosis induced by metal ions and reactive oxygen species
  • preventing lipid peroxidation induced by copper or a free radical generator
  • metal chelator and a potential reactive oxygen species (ROS) scavenger, but its antioxidant properties have not been completely defined (Kim 2002)
  • stress inducible, and expressed during embryogenesis (Tan 2009)
  • zinc RING finger protein that protects mammalian cells from apoptosis by redox reagents, and is a metal chelator and a potential reactive oxygen species scavenger (Lee 2008)
  • may play an important role in regulating the apoptosis induced by heat shock presumably through maintaining the cellular redox status (Lee 2009)
  • is a KRAS-cooperating oncogene that promotes lung tumorigenesis
  • is a RING component of CRL (Cullin-RING ligase), required for its activity
  • is a crucial molecular regulator of retina morphogenesis and cone photoreceptor function
  • plays a differential role in the activation of macrophages and neutrophils
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text cell cycle regulation
    PATHWAY
    metabolism
    signaling
    a component
  • component of the anaphase-promoting complex subunit
  • RING component of SCF E3 ubiquitin ligase (He 2007)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • copper Cu2+
  • protein
  • cullins
  • beta subunit of CKII(CSNK2B)
  • promoting S phase entry and cell growth under serum starvation associated with the inhibition of p27 (CDK1B) accumulation
  • prefers to bind with Cul-5/SOCS (Tan 2009)
  • regulates neuronal migration through different CUL5-RING ligase adaptors
  • CUL5 is a scaffold protein that recruits RNF7, the ELOB/ELOC complex, and SOCS box proteins
  • RNF7 is an E3 ligase that promotes ubiquitylation and degradation of PHLPP1 and DEPTOR, leading to activation of the PI3K/AKT/MTOR axis, whereas RNF7 knockdown caused their accumulation
  • RNF7 functions as a negative regulator of the NFKB1-activating capacity of CARD14
  • cell & other
    REGULATION
    Other sensitive to apoptosis
    regulated by CNSK2A1 (CNSK2A1 might regulate RNF7-SCF E3 ligase activity through modulating RNF7 stability, rather than its enzymatic activity directly) (He 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    progressively from early-to-late stage of human prostate cancer with the highest expression seen in metastatic lesion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a candidate gene for good prognosis, in rectal cancer, independent of therapeutic response of different individuals
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    targeting RNF7 E3 ligase may, therefore, have therapeutic value for the treatment of prostate cancer associated with PTEN loss (pM
    ANIMAL & CELL MODELS