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FLASH GENE
Symbol RNF7 contributors: mct/npt - updated : 21-10-2009
HGNC name ring finger protein 7
HGNC id 10070
Location 3q23      Physical location : 141.457.050 - 141.465.242
Synonym name
  • sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2
  • zinc RING finger protein SAG
  • CKII beta-binding protein 1
  • Synonym symbol(s) CKBBP1, ROC2, SAG, RBX2
    DNA
    TYPE functioning gene
    STRUCTURE 8.19 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391582 3 similar to ATP synthase lipid-binding protein, mitochondrial precursor (ATP synthase proteolipid P1) (ATPase protein 9) (ATPase subunit C) LOC389150 3 LOC389150 FOXL2 3q23 forkhead box L2 LOC389151 3 hypothetical gene supported by AK127998 LOC389152 3 hypothetical gene supported by AK128089 BPESC1 3q23 blepharophimosis, epicanthus inversus and ptosis, candidate 1 MRPS22 3q23 mitochondrial ribosomal protein S22 COPB2 3q23 coatomer protein complex, subunit beta 2 (beta prime) RBP2 3q23 retinol binding protein 2, cellular ACTGP1 3q22.3 actin, gamma pseudogene 1 RBP1 3q23 retinol binding protein 1, cellular NMNAT3 3q12.1-3q13.11 nicotinamide nucleotide adenylyltransferase 3 FLJ11827 3q22.3 hypothetical protein FLJ11827 CLSTN2 3q23-q24 calsyntenin 2 TRIM42 3q23-24 tripartite motif-containing 42 LOC391583 3 similar to 60S ribosomal protein L23a FLJ10618 3q23 hypothetical protein FLJ10618 SSB4 3q23 SPRY domain-containing SOCS box protein SSB-4 FLJ23751 3q23 hypothetical protein FLJ23751 FLJ35036 3q23 hypothetical protein FLJ35036 LOC391584 3 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) RASA2 3q22-q23 RAS p21 protein activator 2 LOC389153 3 LOC389153 LOC391585 3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) RNF7 3q22-q24 ring finger protein 7 GPRK7 3q21-q24 G protein-coupled receptor kinase 7 ATP1B3 3q22-q23 ATPase, Na+/K+ transporting, beta 3 polypeptide TFDP2 3q23 transcription factor Dp-2 (E2F dimerization partner 2) MGC40579 3q23 hypothetical protein MGC40579 SEP1 3q23 strand-exchange protein 1 ATR 3q22-q24 ataxia telangiectasia and Rad3 related PLS1 3q23 plastin 1 (I isoform) TRPC1 3q22-q24 transient receptor potential cation channel, subfamily C, member 1 PCOLCE2 3q21-q24 procollagen C-endopeptidase enhancer 2 PAQR9 3q23 progestin and adipoQ receptor family member IX SR140 3q23-q24 progestin and adipoQ receptor family member IX LOC389154 3 LOC389154 CHST2 3q24 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 PBXP1 3q22-q23 pre-B-cell leukemia transcription factor pseudogene 1 SLC9A9 3p14 solute carrier family 9 (sodium/hydrogen exchanger), isoform 9 LOC257039 3q24 similar to ribosomal protein S17 MGC33365 3q24 hypothetical protein MGC33365
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1609 - 90 - Swaroop (1999)
    3 - 1599 - 113 - Swaroop (1999)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticthymus   highly
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SKP1/cullin/F box domain
  • zinc RING finger domain at the C terminus
  • conjugated PhosphoP , MetalloP
    HOMOLOGY
    interspecies homolog to murine Rnf7
    intraspecies homolog to APC11 (ANAPC11)
    Homologene
    FAMILY
  • SKP1-cullin F box protein (SCF) E3 ubiquitin ligase family
  • RING-box family (RBX) family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • mainly localized in nucleus and lightly in cytoplasm (He 2007)
  • basic FUNCTION
  • protective molecule,acting as an antioxidant to inhibit apoptosis induced by metal ions and reactive oxygen species
  • preventing lipid peroxidation induced by copper or a free radical generator
  • metal chelator and a potential reactive oxygen species (ROS) scavenger, but its antioxidant properties have not been completely defined (Kim 2002)
  • stress inducible, and expressed during embryogenesis (Tan 2009)
  • zinc RING finger protein that protects mammalian cells from apoptosis by redox reagents, and is a metal chelator and a potential reactive oxygen species scavenger (Lee 2008)
  • may play an important role in regulating the apoptosis induced by heat shock presumably through maintaining the cellular redox status (Lee 2009)
  • CELLULAR PROCESS cell life, proliferation/growth
    cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    text cell cycle regulation
    PATHWAY
    metabolism
    signaling
    a component
  • component of the anaphase-promoting complex subunit
  • RING component of SCF E3 ubiquitin ligase (He 2007)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • copper Cu2+
  • protein
  • cullins
  • beta subunit of CKII(CSNK2B)
  • promoting S phase entry and cell growth under serum starvation associated with the inhibition of p27 (CDK1B) accumulation
  • prefers to bind with Cul-5/SOCS (Tan 2009)
  • cell & other
    REGULATION
    Other sensitive to apoptosis
    regulated by CNSK2A1 (CNSK2A1 might regulate RNF7-SCF E3 ligase activity through modulating RNF7 stability, rather than its enzymatic activity directly) (He 2007)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS