Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNF6 contributors: - updated : 18-12-2006
HGNC name ring finger protein (C3H2C3 type) 6
HGNC id 10069
Location 13q12      Physical location : 26.786.905 - 26.796.508
DNA
TYPE functioning gene
STRUCTURE 9.00 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
MIPEP 13q12 mitochondrial intermediate peptidase LOC387911 13 similar to hypothetical protein MGC48915 LOC390384 13 similar to hypothetical protein DKFZp434A171 SPATA13 13q12.13 spermatogenesis associated 13 MGC48915 13q12.13 hypothetical protein MGC48915 LOC390385 13 similar to hypothetical protein, MGC:7199 HCP33 13q12.13 cytochrome c, somatic pseudogene ADPRTL1 13q11 ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 1 LOC387912 13 similar to TPTE and PTEN homologous inositol lipid phosphatase ATP12A 13q12.1-q12.3 ATPase, H+/K+ transporting, nongastric, alpha polypeptide LOC390386 13 similar to hypothetical protein DKFZp434A171 RNF17 13q12 ring finger protein 17 TDRD4 13q12.12 tudor domain containing 4 CENPJ 13q12.13 centromere protein J LOC387913 13 similar to TPTE and PTEN homologous inositol lipid phosphatase LOC390387 13 similar to Striatin PABPC3 13q11-q12 poly(A) binding protein, cytoplasmic 3 FLJ25477 13q12.13 hypothetical protein FLJ25477 MTMR6 13q12 myotubularin related protein 6 NUPL1 13q12.12 nucleoporin like 1 LOC246717 13q12 transcription elongation factor B (SIII), polypeptide 2 (18kD, elongin B) pseudogene ATP8A2 13q12-13 ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2 LOC387914 13 similar to WGAR9166 RNF6 13q12 ring finger protein (C3H2C3 type) 6 CDK8 13q12 cyclin-dependent kinase 8 WASF3 13q12 WAS protein family, member 3 LOC390389 13 similar to ribosomal protein S3a; 40S ribosomal protein S3a; v-fos transformation effector protein 1 GPR12 13q12 G protein-coupled receptor 12 USP12 5q33-q34 ubiquitin specific protease 12 RPL21 13pter-p13 ribosomal protein L21 LOC254109 13q12.2 similar to MGC53580 protein GTF3A 13q12.3-q13.1 general transcription factor IIIA MTIF3 13q12.2 mitochondrial translational initiation factor 3 PDZRN1 13q12.2 PDZ domain containing ring finger 1 MGC9850 13q12.2 hypothetical protein MGC9850 POLR1D 13q12.2 polymerase (RNA) 1 polypeptide D, 16kDa GSH1 13q12.13 GS homeobox 1 IPF1 13q12.1 insulin promoter factor 1, homeodomain transcription factor LOC387915 13 hypothetical gene supported by AK000246 CDX2 13q12-q13 caudal type homeo box transcription factor 2 FLT3 13q12 fms-related tyrosine kinase 3 LOC390390 13 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein LOC390391 13 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) PAN3 13q12.2 PABP1-dependent poly A-specific ribonuclease subunit PAN3 FLT1 13q12 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) LOC341784 13q12.3 similar to eukaryotic translation initiation factor 4A1; initiation factor eIF-4A long form
regionally located close to marker D13S1121 oriented from telomere to centromere
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 3503 78 685 - Macdonald, 99
- splicing 3300 78 685 - Macdonald, 99
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
Reproductivefemale systemovary  lowly
 male systemprostate  lowly
 male systemtestis  lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a coiled coil domain and a C terminal ring-H2 (C3H2C3) finger domain with a short KIL motif upstream of the RING domain
conjugated MetalloP
HOMOLOGY
Homologene
FAMILY RING finger protein family
CATEGORY regulatory , transcription factor , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION potential tumor suppressor gene involved in the pathogenesis of esophageal squamous cell carcinoma.
CELLULAR PROCESS nucleotide, transcription, regulation
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA binding
RNA
small molecule metal binding,
zinc Zn2+
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s)
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
ANIMAL & CELL MODELS