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FLASH GENE
Symbol RNF5 contributors: mct - updated : 03-11-2015
HGNC name ring finger protein 5
HGNC id 10068
Location 6p21.31      Physical location : 3.407.181 - 32.148.567
Synonym name
  • E3 ubiquitin-protein ligase RNF5
  • protein G16
  • ram1 homolog
  • Synonym symbol(s) RING5, NG2, G16, RMA1
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 2.41 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    BAT8 6p21.31 HLA-B associated transcript 8 C6orf46 6p21.31 chromosome 6 open reading frame 46 C2 6p21.3 complement component 2 BF 6p21.3 B-factor, properdin RDBP 6p21.33 RD RNA binding protein SKIV2L 6p21.3 superkiller viralicidic activity 2-like (S. cerevisiae) DOM3Z 6p21.3 dom-3 homolog Z (C. elegans) STK19 6p21.3 serine/threonine kinase 19 C4B 6p21.3 complement component 4B CYP21A2 6p21.3 cytochrome P450, family 21, subfamily A, polypeptide 2 TNXB 6p21.3 tenascin XB CREBL1 6p21.3 cAMP responsive element binding protein-like 1 FKBPL 6p21.3 FK506 binding protein like C6orf31 6p21.1 chromosome 6 open reading frame 31 PPT2 6p21.3 palmitoyl-protein thioesterase 2 EGFL8 6p21.31 EGF-like-domain, multiple 8 AGPAT1 6p21.3 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) RNF5 6p21.31 ring finger protein 5 AGER 6p21.3 advanced glycosylation end product-specific receptor PBX2 6p21.3 pre-B-cell leukemia transcription factor 2 C6orf9 6p21.3 chromosome 6 open reading frame 9 NOTCH4 6p21.3 Notch homolog 4 (Drosophila) C6orf10 6p21.3 chromosome 6 open reading frame 10 BTNL2 6p21.3 butyrophilin-like 2 (MHC class II associated)
    regionally located proximal to the MHC region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1176 - 180 - 1997 9533025
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a ring (C3HC4-type) zinc finger motif
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to C.elegans (putative zinc finger gene)
    Homologene
    FAMILY RING finger protein family
    CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus,chromatin/chromosome
    text
  • anchored to the outer membrane of the ER
  • both TMEM173 and RNF5 were located at the mitochondria and endoplasmic reticulum (ER) and viral infection caused their redistribution to the ER and mitochondria, respectively
  • basic FUNCTION
  • E3 ubiquitin ligase implicated in motility and endoplasmic reticulum stress response
  • ER-anchored RING finger E3 ligase implicated in muscle organization and in recognition and processing of malfolded proteins
  • importance of RNF5 in muscle physiology and its deregulation in ER stress associated muscular disorders
  • regulator of breast cancer progression through its effect on actin cytoskeletal alterations, which also affect sensitivity of breast cancer cells to cytoskeletal targeting antineoplastic agents
  • is a ubiquitin ligase anchored to the ER membrane implicated in ERAD via ubiquitination of misfolded proteins
  • negatively regulates virus-triggered signaling by targeting TMEM173 for ubiquitination and degradation at the mitochondria
  • RNF5-mediated ubiquitination and degradation of MAVS is one of the mechanisms of the regulation of virus-triggered induction of type I IFNs and cellular antiviral response
  • is involved in Pendrin (SLC26A4) degradation
  • RNF5-mediated control of membranal ATG4B reveals a novel layer in the regulation of ATG8 processing and autophagy
  • RNF5 regulates the turnover of specific G protein-coupled receptors by ubiquitinating JKAMP and preventing proteasome recruitment
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • RNF5 effect on JKAMP is seen prior to and after ER stress response, thereby highlighting a novel mechanism to limit ERAD and proteasome assembly at the ER, to the actual ER stress response
  • RNF5 negatively regulates virus-triggered signaling by targeting TMEM173 for ubiquitination and degradation at the mitochondria
  • interacted with MAVS at mitochondria in a viral infection-dependent manner
  • regulates basal levels of autophagy by controlling the stability of a select pool of the cysteine protease ATG4B
  • interaction between RNF5 and the ADRB2 as well as the prostaglandin D2 receptor (DP)
  • RNF5 ubiquitinated JNK-associated membrane protein (JKAMP), a protein that recruits the proteasome to the ER membrane and that is negatively regulated by RNF5-mediated ubiquitination
  • RNF185 and RNF5 are a novel E3 ligase module central to the control of CFTR degradation
  • SYVN1 and RNF5 may be negative regulators of disease-associated transporter ABCG5/ABCG8
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer with decreased survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratoryCF (mucoviscidosis) 
    RNF5 is a target for therapeutic modalities to antagonize mutant CFTR proteins
    ANIMAL & CELL MODELS