basic FUNCTION
| involved in the protein and DNA association in the nucleus of the cell |
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functions as an E3 ligase and this activity is closely linked to its transcription regulatory functions |
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involved in transcriptional and cell growth regulation |
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poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation |
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coregulator of seroid receptor-mediated gene transcription |
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SUMO-targeted ubiquitin ligase that mediates heat-shock-inducible ubiquitination of PARP1, regulates the stability of PARP1, and, like PIAS4, is a positive regulator of HSPA1A gene activity |
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with VHL regulate the proteasomal degradation of SUMO-conjugated HIF2A |
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finely balanced activities of SENP6 and RNF4 control vertebrate kinetochore assembly through SUMO-targeted destabilization of inner plate components |
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RING E3 ligase that regulate the homoeostasis of SUMOylated proteins by promoting their ubiquitylation |
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SUMO-dependent ubiquitin E3-ligase implicated in maintaining genome stability, and playing a key role in active DNA demethylation |
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may serve as a direct link between epigenetic DNA demethylation and DNA repair in mammalian cells |
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gene essential for mammalian embryonic development, playing a critical role in active DNA demethylation through mechanisms that involve the BER (base excision repair) pathway |
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RING E3 ligase that regulate the homoeostasis of SUMOylated proteins by promoting their ubiquitylation |
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is a dimeric RING ubiquitin E3 ligase that ubiquitylates poly-SUMOylated proteins |
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operates as a DSB response factor at the crossroads between the SUMO and ubiquitin systems |
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is a novel DNA damage-responsive protein that plays a role in homologous recombination and integrates SUMO modification and ubiquitin signaling in the cellular response to genotoxic stress |
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is a critical component of the DDR ( DNA damage response)and RNF4 controls potentially protein localization at DNA damage sites by integrating SUMOylation and ubiquitylation events |
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ARM is required for RNF4 to efficiently target Ser(P)-824-SUMO-KAP1, conferring ubiquitin Lys-48-mediated proteasomal degradation in the context of double strand breaks |
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manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer |
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plays a novel role in preventing the loss of intact chromosomes and ensures the maintenance of chromosome integrity 0) |
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is an E3 ubiquitin ligase originally identified as a transcription co-activator |
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antagonizes transcriptional repression mediated by DNA methylation |
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is a SUMO-targeted ubiquitin E3 ligase with a pivotal function in the DNA damage response (DDR) |
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USP11 and RNF4 as a balanced SUMO-targeted ubiquitin ligase/protease pair with a role in the DDR |
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RNF4 and TRIM28 play critical roles in the response to DNA double-strand breaks (DSBs) |
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combined effect of dynamic recruitment of RNF4 to TRIM28 regulates likely the relative occupancy of TP53BP1 and BRCA1 at DSB sites to direct DSB repair in a cell cycle-dependent manner |
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