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FLASH GENE
Symbol RNF39 contributors: mct - updated : 19-04-2011
HGNC name ring finger protein 39
HGNC id 18064
Location 6p21.33      Physical location : 1.278.274 - 30.043.628
Synonym name
  • LTR (long-term potentiation) induced RING finger
  • HZFw1 protein
  • Synonym symbol(s) LIRF, HZF, HZFW, HZFW1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, overlapping, gene in gene, antisens
    text sense/antisense mRNA overlapping
    STRUCTURE 5.87 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked Y status provisional
    Physical map
    P5-05 6p21.3 P5-1 pseudogene HLA-K 6p21.3 major histocompatibility complex, class I, K HLA-21 6p21.3 HLA-21 pseudogene P5.8 6p21.3 P5-1 pseudogene HCGIV-05 HLA-A 6p21.3 major histocompatibility complex, class I, A P5-03 HCGIV-04 HLA-80 6p21.3 HLA-80 pseudogene HCGII-6 MICD 6p21.3 MHC class I polypeptide-related sequence D HCGIX 3.8-1.2 6p21.3 3.8-1.2 pseudogene P5-02 HLA-J 6p21.3 major histocompatibility complex, class I, J (pseudogene) ETF1P1 6p21.3 eukaryotic translation termination factor 1 pseudogene 1 C6orf12 6p22.1 chromosome 6 open reading frame 12 ZNRD1 6p21.3 zinc ribbon domain containing, 1 PPP1R11 6p21.3 protein phosphatase 1, regulatory (inhibitor) subunit 11 RNF39 6p21.3 ring finger protein 39 TRIM31 6p21.3 tripartite motif-containing 31
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 splicing 2170 45.5 420 - 2000 11130983
  • also called HZFw1
  • 4 exons
  • 5 splicing 1970 38.2 354 - 2000 11130983
  • also called HZFw2
  • 5 exons
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus  
    Reproductivemale systemtestis   
    Respiratorylung    
    Urinarykidney    
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Epithelialabsorptive excretoryalveolar epithelium  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     granular cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES Hydrophilic
    STRUCTURE
    motifs/domains
  • an N terminal Ring-type zinc finger
  • a C terminal B30.2 domain
  • a putative PEST sequence
  • HOMOLOGY
    interspecies ortholog to murine Rnf39-pending
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • possible involvement in a limited early phase of synaptic plasticity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    induced by Long Term Potentiation
    Other coregulation by CIS-interaction in gene expression
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Behcet disease (BD)
    Variant & Polymorphism SNP
  • SNP rs9261365 near RNF39, associated with Behcet disease (BD)
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    therapeutic target against Behcet disease
    ANIMAL & CELL MODELS