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FLASH GENE

Symbol

RNF39

contributors: mct - updated : 19-04-2011

HGNC name	ring finger protein 39
HGNC id	18064

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.33      Physical location : 1.278.274 - 30.043.628
Synonym name	LTR (long-term potentiation) induced RING finger
	HZFw1 protein
Synonym symbol(s)	LIRF, HZF, HZFW, HZFW1

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster, overlapping, gene in gene, antisens
text	sense/antisense mRNA overlapping
STRUCTURE	5.87 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_025236 4 splicing 2170 NP_079512 45.5 420 - 2000 11130983 also called HZFw1 4 exons NM_170769 5 splicing 1970 NP_739575 38.2 354 - 2000 11130983 also called HZFw2 5 exons

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus     Reproductive male system testis       Respiratory lung         Urinary kidney         Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial         Epithelial absorptive excretory alveolar epithelium

cells

System Cell Pubmed Species Stage Rna symbol   granular cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophilic
STRUCTURE

motifs/domains	an N terminal Ring-type zinc finger
	a C terminal B30.2 domain
	a putative PEST sequence

HOMOLOGY

interspecies

ortholog to murine Rnf39-pending

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION

possible involvement in a limited early phase of synaptic plasticity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

induced by

Long Term Potentiation

Other

coregulation by CIS-interaction in gene expression

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to Behcet disease (BD)

Variant & Polymorphism SNP	SNP rs9261365 near RNF39, associated with Behcet disease (BD)

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   therapeutic target against Behcet disease

ANIMAL & CELL MODELS