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FLASH GENE
Symbol RNF34 contributors: mct - updated : 20-02-2012
HGNC name ring finger protein 34
HGNC id 17297
Location 12q24.31      Physical location : 121.837.901 - 121.862.155
Synonym name
  • RING finger protein RIFF
  • RING finger homologous to IAP type
  • caspase regulator CARP1
  • caspases-8 and -10-associated RING finger protein 1
  • Synonym symbol(s) RIFF, FLJ21786, EVI68, RFI, CARP-1
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 24.25 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 2105 41 373 - 2002 12118383
    6 splicing 2039 - 372 - 2002 12118383
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Nervousbrain    
     nervecranial nerve  highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING zinc finger motif
  • a cytochrome C-heme-binding site
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY ring finger protein family
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,chromatin/chromosome
    intracellular,nuclear envelope
    basic FUNCTION
  • having an anti-apoptotic function
  • playing an impartant role in colorectal carcinogenesis through its effect on apoptosis regulation
  • may act as an oncogenic molecule affecting the apoptotic pathway
  • with RFFL, stabilize MDM2 by inhibiting MDM2 self-ubiquitination
  • with RFFL, enhance TP53 turnover by degrading YWHAS and stabilizing MDM2
  • is a bona fide E3 ubiquitin ligase for PPARGC1A and negatively regulates brown fat cell metabolism
  • CELLULAR PROCESS cell life, antiapoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • interacting and antagonizing DNAJA3
  • REFFL and RNF34 together with MDM2 enhance TP53 degradation, thereby inhibiting TP53-mediated cell death
  • specific E3 ubiquitin ligase for PPARGC1A (nuclear protein that interacts with and ubiquitinates PPARGC1A to promote its turnover)
  • RNF34 is a negative regulator of the NOD1 pathway through direct interaction and ubiquitination of NOD1, and suggest a novel regulatory mechanism of NOD1
  • cell & other
    REGULATION
    Other cleaved by caspase 3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal cancer
    tumoral     --over  
    in colorectal carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    might be a novel therapeutic target for gene therapy in colorectal cancer
    ANIMAL & CELL MODELS