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FLASH GENE
Symbol RNF219 contributors: mct - updated : 06-10-2009
HGNC name ring finger protein 219
HGNC id 20308
Location 13q31.1      Physical location : 79.188.420 - 79.233.314
Synonym name chromosome 13 open reading frame 7
Synonym symbol(s) FLJ13449, FLJ25774, C13orf7, DKFZp686A01276, DKFZp686N15250, DKFZp686O03173
DNA
TYPE functioning gene
STRUCTURE 44.89 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3552 - 726 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Lymphoid/Immunelymph node   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a ring-type zinc finger domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Late-onset Alzheimer disease (LOAD)
    Variant & Polymorphism other
  • genetic variant within RNF219 was found to affect amyloid deposition in human brain and LOAD age-of-onset
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS