Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNF19A contributors: npt - updated : 12-05-2005
HGNC name ring finger protein 19A
HGNC id 13432
Location 8q22      Physical location : 101.269.287 - 101.322.327
Synonym name
  • double ring-finger protein, dorfin
  • ring-IBR-ring domain containing protein Dorfin
  • ring finger protein 19
  • E3 ubiquitin-protein ligase RNF19A
  • Synonym symbol(s) DORFIN, RNF19, DKFZp566B1346, p38
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 53.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two variants encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 4366 90 838 - -
    - - 4357 90 838 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Nervousspinal cord    
    Reproductivefemale systemuterus   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text kidney and testis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an IBR (in between RING fingers) motif at the N terminus
  • two RING-finger motifs
  • HOMOLOGY
    Homologene
    FAMILY
  • RING finger type ubiquitin ligase family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text localized in Lewy bodies
    basic FUNCTION
  • mediating ubiquitination of cellular proteins
  • may be involved in the pathogenic process of Parkinson disease and Lewy bodies formation by ubiquitylation of synphilin-1 (SNCAIP)
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes
  • binding and ubiquitylating synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of Lewy-Bodies
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS