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FLASH GENE
Symbol RNF186 contributors: mct - updated : 09-07-2014
HGNC name ring finger protein 186
HGNC id 25978
Location 1p36.13      Physical location : 20.140.522 - 20.141.771
DNA
TYPE functioning gene
STRUCTURE 1.25 kb     1 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 1268 - 227 - 2013 2389612
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • ER locating RING finger E3 ligase RNF186 participates in the process of ER stress-mediated apoptosis
  • can arouse stress signaling at ER
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BNIP1 is one of the substrates of RNF186 (pMID; 23896122)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS