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FLASH GENE
Symbol RNF182 contributors: mct - updated : 08-09-2021
HGNC name ring finger protein 182
HGNC id 28522
Location 6p23      Physical location : 13.924.676 - 13.980.239
Synonym symbol(s) FLJ40772, MGC33993
EC.number 2.3.2.27
DNA
TYPE functioning gene
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3684 - 247 - 2020 32486221
4 - 3712 - 247 - 2020 32486221
3 - 3629 - 247 - 2020 32486221
2 - 3664 - 247 - 2020 32486221
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   predominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • is a low abundance cytoplasmic protein expressed preferentially in the brain
  • it may play a very specific role in controlling the turnover of an essential component of neurotransmitter release machinery
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between RNF182 and ATP6V0C, known for its role in the formation of gap junction complexes and neurotransmitter release channels
  • RNF182 promotes the degradation of RELA via K48-linked ubiquitination, resulting in the inhibition of TLR-triggered innate immune responses
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS