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FLASH GENE
Symbol RNF181 contributors: mct/npt - updated : 11-06-2008
HGNC name ring finger protein 181
HGNC id 28037
Location 2p11.2      Physical location : 85.822.836 - 85.824.831
Synonym symbol(s) HSPC238, RN181
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 716 17 153 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrineadrenal gland   highly
 neuroendocrinepituitary  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING (Really Interesting New Gene)-type zinc-finger domain suggestive of a possible role in protein ubiquitination pathways
  • HOMOLOGY
    Homologene
    FAMILY
  • RNF181 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • having ubiquitin E3 ligase activity
  • playing a role in integrin and platelet signaling
  • having a functional role as an E3 ligase in platelets
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS