basic FUNCTION
| recruited to sites of DNA damage by binding to ubiquitylated histone H2A |
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chromatin-associated RING finger protein which targets histones HIST2H2AC and H2AFX) |
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acting with UBE2N to amplify the RNF8-dependent histone ubiquitylation by targeting H2A-type histones and by promoting the formation of lysine 63-linked ubiquitin conjugates |
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E3 ubiquitin ligase that acts in concert with UBE2N to catalyze the formation of lysine 63 (K63)-linked ubiquitin conjugates and promotes the ubiquitylation of H2A-type histones surrounding the damage |
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chromatin-associated ubiquitin ligase with an ability to bind ubiquitin |
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ubiquitin-dependent DNA-damage signaling cascade involving the E34 ubiquitin ligases RNF8 and RNF168 plays key roles in coordinating cell cycle progression and DNA repair |
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combines E3 ubiquitin ligase activity with an ability to bind conjugated ubiquitin on damaged chromosomes and mechanistically defines a molecular pathway involved in the DNA damage-induced chromatin response |
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chromatin-associated RING finger protein, targeting histones HIST2H2AC and H2AFX |
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facilitate recruitment of TP53BP1 to sites of DNA damage and the ubiquitination pathway mediated by RNF8 and RNF168 plays an integral part in class switch recombination |
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with others ATM signalling mediator proteins, RNF8, MDC1 and TP53BP1 are also required for heterochromatic DSB repair |
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RNF8 and RNF168 effect the formation of lysine 63-linked polyubiquitin (K63Ub) chains on damaged chromatin, including on histones HIST2H2AC and H2AFX, in an ATM-dependent manner |
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contributes to this emerging pathway of several E3 ubiquitin ligases that perform sequential ubiquitylations on damaged chromosomes, chromatin modifications essential for aggregation of repair complexes at the DSB sites |
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E3 ubiquitin ligases RNF8 and RNF168 may participate in cellular responses upon replication stress |
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HERC2 and RNF168 are novel DNA damage-dependent SUMOylation targets in human cells |
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RNF8 and RNF168 are essential RING-E3 ubiquitin ligases that catalyze the formation of Lys-63 ubiquitin chains in the DNA damage response |
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histone ubiquitination during the DSB pathway is initiated by RNF168 on HIST2H2AC and H2AFX, whereas RNF8 is inactive toward them |
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RNF168 and TP53BP1 have a similar influence on homologous recombination (HR) and also indicate that these factors may function in the same pathway to inhibit HR |
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RNF168 is important for HR deficiency in cells with BRCA1 silencing |
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RNF8 and RNF168 operate in different modes with their cognate E2 UBE2N at DSBs |
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RNF168, in complex with UBE2A or UBE2B, is activated in the DNA-damage-induced protein ubiquitination cascade |
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plays a central role in the regulation of TP53BP1 functions |
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multistep roles of RNF168 in signaling DNA damage |
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nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A |
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RNF8 is less abundant than RNF168, and RNF8 is a rate-limiting determinant of focal repair complex assembly |
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promotes noncanonical K27-linked ubiquitination |