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FLASH GENE
Symbol RNF167 contributors: mct - updated : 10-10-2018
HGNC name ring finger protein 167
HGNC id 24544
Location 17p13.2      Physical location : 4.843.629 - 4.848.515
Synonym name E3 ubiquitin-protein ligase RNF167
Synonym symbol(s) LP2254, DKFZP566H073, 5730408C10Rik, RING105
EC.number 6.3.2.-/ 2.3.2.27
DNA
TYPE functioning gene
STRUCTURE 4.89 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 1723 38 350 - 2012 23129617
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Endocrinepancreasislet of Langerhans  highly Homo sapiens
Nervousbrainforebraincerebral cortex   Rattus norvegicusAdult
 brainlimbic systemhippocampus   Rattus norvegicusAdult
 brain   lowly Homo sapiens
Reproductivemale systemtestis  highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal transmembrane (TM) domain
  • a protease-associated domain, with a functional role for the PA domain, which is required for endosomal localization of the protein
  • a second TM domain
  • a putative PEST sequence (Yamada 2006)
  • a signal peptide,
  • a central membrane-spanning region,
  • a C-terminal RING (really interesting new gene) domain
  • two putative N-terminal glycosylation sites
  • HOMOLOGY
    interspecies homolog to drosophila Godzilla
    Homologene
    FAMILY PA domain-containing E3 family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • type I transmembrane protein
  • basic FUNCTION
  • RING-finger protein, ubiquitin ligase for SLC22A18 that can function in concert with the ubiquitin-conjugating enzyme UBE2E1
  • RNF167 is a selective regulator of AMPAR-mediated neurotransmission
  • is an endosomal ubiquitin ligase that regulates AMPAR-mediated synaptic transmission
  • influences the activity-dependent ubiquitination of neuronal AMPARs and regulates AMPA receptor-mediated synaptic transmission
  • implicated in the regulation of cellular endosome trafficking
  • RNF167 plays a crucial role as an E3 ubiquitin ligase targeting ARL8B to regulate lysosome positioning and endocytic trafficking
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    UBE2E1-RNF167 may define a novel ubiquitin-proteasome pathway that targets SLC22A18 in cells
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with UBE2E1 and SLC22A18
  • RNF167 is involved in activity-dependent ubiquitination of AMPARs
  • is an E3 ligase that ubiquitinates GRIA2 and regulates its surface expression
  • RNF167 ubiquitinates ARL8B at the lysine residue K141 and reduces the level of the ARL8B protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS