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FLASH GENE
Symbol RNF149 contributors: mct - updated : 21-03-2013
HGNC name ring finger protein 149
HGNC id 23137
Location 2q11.2      Physical location : 101.892.062 - 101.925.178
Synonym name DNA polymerase-transactivated protein 2
Synonym symbol(s) DNAPTP2
DNA
TYPE functioning gene
STRUCTURE 33.12 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2968 - 400 - 2012 22628551
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • a PA domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    basic FUNCTION
  • ubiquitin protein ligase activity
  • attenuated the increase in cell growth induced by wild-type BRAF
  • E3 ubiquitin ligase active on wild-type BRAF
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • bound directly to the C-terminal kinase-containing domain of BRAF and induced ubiquitination, followed by proteasome-dependent degradation, of the latter protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS