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FLASH GENE
Symbol RNF14 contributors: mct/npt - updated : 02-07-2008
HGNC name ring finger protein 14
HGNC id 10058
Location 5q31.3      Physical location : 141.346.436 - 141.368.752
Synonym name
  • androgen receptor associated protein 54
  • E3 ubiquitin-protein ligase RNF14
  • Synonym symbol(s) HFB30, ARA54, FLJ26004, HRIHFB2038, TRIAD2
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 22.32 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    PCDHGC3 5q31.3 protocadherin gamma subfamily C, 3 PCDHGC4 5q31.3 protocadherin gamma subfamily C, 4 PCDHGC5 5q31.3 protocadherin gamma subfamily C, 5 DIAPH1 5q31-q32 diaphanous homolog 1 (Drosophila) HDAC3 5q31.3 histone deacetylase 3 FLJ90583 FLJ00007 5q31.3 hypothetical protein FLJ00007 ARAP3 5q31.3 ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3 PCDH1 5q31-q32 protocadherin 1 (cadherin-like 1) LOC285615 5q31.3 similar to dJ702J19.1 (glycine cleavage system protein H (aminomethyl carrier)) KIAA0141 5q31.3 similar to dJ702J19.1 (glycine cleavage system protein H (aminomethyl carrier)) PCDH12 5q31.3 protocadherin 12 RNF14 5q23.3-q31.1 ring finger protein 14 GNPDA1 5q21 glucosamine-6-phosphate deaminase 1 MRPL11P2 5q31.3 glucosamine-6-phosphate deaminase 1 NDFIP1 5q31.3 Nedd4 family interacting protein 1 SPRY4 5q31.3 sprouty homolog 4 (Drosophila)
    RNA
    TRANSCRIPTS type messenger
    text several transcripts
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3144 - 474 - Kikuchi (2007)
    8 - 2992 - 348 - Kikuchi (2007)
    8 - 2892 - 474 - Kikuchi (2007)
    - - 2970 - 474 - Kikuchi (2007)
    9 - 3100 - 474 - Kikuchi (2007)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrineadrenal gland   predominantly
     parathyroid   highly
    Nervousnerve   highly
    Reproductivefemale systemuterus   
     male systemtestis   
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RING (C3HC4-type) zinc finger motif
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • RING finger protein family
  • CATEGORY transcription factor , signaling hormone
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • coactivator of AR mediated transactivation in prostate, effect inhibited by a RNF14 (ARA54) dominant negative mutation
  • androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation
  • playing a role in the regulation of cyclin D1 expression in the absence of AR stimulation in cancer cells
  • might participate in enhancing cell cycle progression and cell proliferation via induction of cyclin D1 (CCND1)(Kikuchi 2007)
  • androgen receptor (AR) co-activator that enhances AR-dependent transcriptional activation (Kikuchi 2007)
  • may play an important role in testicular development and spermatogenesis in humans (Lan 2008)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    decreased expression is a feature of nonobstructive azoospermia (Lan 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS