SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,lysosome
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,nucleus,nucleoplasm
|
| intracellular,nucleus,chromatin/chromosome
|
text
| is highly enriched in ER |
basic FUNCTION
| maybe involved in protein-protein integration |
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putative E3 ubiquitin-ligase activity intrinsic to the RING domain |
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is an E3 ubiquitin ligase embedded in endosome membranes |
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RNF13, with its ubiquitin ligase-active RING domain, has the potential to turn over key nuclear proteins in response to signals received at the plasma membrane |
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RNF13 expression is developmentally regulated during myogenesis and is upregulated in various tumors |
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acting as an ubiquitin ligase, might likely have profound biological functions during development and disease |
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RNF13 is likely involved in the regulation of the SNARE complex, which thereby controls synaptic function |
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RNF13 is likely a critical mediator for facilitating ER stress-induced apoptosis through the activation of the ERN1-TRAF2-JNK signaling pathway |
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inflammatory cells are important in RNF13-mediated satellite cell functions |
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is a novel E3 ubiquitin ligase whose expression is associated with cancer development |
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involved in neuronal development |