Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RNF125 contributors: mct/pgu - updated : 09-07-2014
HGNC name ring finger protein 125
HGNC id 21150
Location 18q12.1      Physical location : 29.598.444 - 29.653.154
Synonym name
  • T-cell RING protein in activation 1
  • T-cell ring protein identified in activation screen
  • E3 ubiquitin-protein ligase RNF125
  • Synonym symbol(s) FLJ20456, MGC21737, TRAC1, TRAC-1
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 54.71 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DSC3 18q12.1 desmocollin 3 DSC2 18q12.1 desmocollin 2 DSC1 18q12.2 desmocollin 1 DSG1 18q12.1 desmoglein 1 DSG4 18q12.1 desmoglein 4 DSG3 18q12.1 desmoglein 3 (pemphigus vulgaris antigen) DSG2 18q12.1 desmoglein 2 TTR 18q12.1-q12.2 transthyretin (prealbumin, amyloidosis type I) B4GALT6 18q11 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 LOC390845 18 similar to KIAA0563-related gene LOC390846 18 similar to 27 kDa Golgi SNARE protein (Golgi SNAP receptor complex member 2) (Membrin) MCART2 18q12.1 mitochondrial carrier triple repeat 2 KIAA1012 18q11.2 mitochondrial carrier triple repeat 2 LOC342705 18q12.1 similar to 6-phosphogluconate dehydrogenase, decarboxylating LOC390847 18 similar to epsin 2 isoform a; Eps15 binding protein RNF125 18q12.1 ring finger protein 125 LOC390848 18 similar to 40S ribosomal protein S15a RNF138 18q12.1 ring finger protein 138 MEP1B 18q12.2-q12.3 meprin A, beta FLJ21610 KIAA1384 18q12.1 KIAA1384 protein LOC374864 18q12.1 hypothetical protein LOC374864 LOC147354 18q12.1 similar to additional sex combs like 2; polycomb group protein ASXH2 KIAA1713 18q11 KIAA1713 protein NOL4 18q12 nucleolar protein 4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 5888 - 232 - 2008 17990982
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Reproductivefemale systemuteruscervix  
     male systemtestis   
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal C3HC4 (Cys(3)-His-Cys(4)) RING finger domain, important for E3 ubiquitin protein ligase
  • a C2HC (Cys(2)-His-Cys)- and two C2H2 (Cys(2)-His(2))-type zinc fingers
  • a UIM (ubiquitin-interacting motif), binding Lys(48)-linked polyubiquitin chains and together with the RING domain, required for auto-ubiquitination
  • crucial role for the C-terminus in its function
  • HOMOLOGY
    interspecies homolog to murine 4930553F04Rik
    homolog to rattus LOC361296
    intraspecies paralog to RNF114
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text associates with membranes and is excluded from the nucleus through myristoylation
    basic FUNCTION
  • having E3 ubiquitin ligase activity
  • may function as a positive regulator in the T-cell receptor signaling pathway
  • acts as a ubiquitin E3-ligase regulating the cellular levels of RARRES3 through proteasomal degradation
  • involved in the down-regulation of HIV-1 replication not only in cell lines, but also in peripheral blood mononuclear cells
  • could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway
  • functions as a negative regulator of RARRES3 signaling
  • down-modulating HIV replication and inhibiting pathogen-induced cytokine production
  • regulate the IFIH1/DDX58 innate antiviral response
  • catalysed the conversion of all input protein to higher molecular weight ubiquitinated forms
  • RNF125 plays a new role in innate immune response by regulating TRIM14 ubiquitination and degradation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ion Zn2+
  • protein
  • may play an important role in the regulation of IRF3 activity
  • interacting with UBE2E2 and ISG15
  • RNF125 is a negative regulator of TRIM14 in the innate antiviral immune response
  • cell & other
    REGULATION
    Other UBE2E2 and ISG15 are functional regulators of RNF125 E3 ligase activity, which regulates the level of ubiquitin and ISG15 conjugation of DDX58
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    inhibits TRIM14-mediated antiviral response
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS