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FLASH GENE
Symbol RNF114 contributors: mct/npt/pgu - updated : 10-07-2012
HGNC name ring finger protein 114
HGNC id 13094
Location 20q13.13      Physical location : 48.552.913 - 48.570.420
Synonym name zinc finger protein 313
Synonym symbol(s) ZNF313, ZNF228, PSORS12
DNA
TYPE functioning gene
STRUCTURE 17.51 kb     6 Exon(s)
regulatory sequence Binding site   transcription factor
text structure
  • a functional Sp1 binding site was identified
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2478 25.7 228 - 2008 18364390
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Lymphoid/Immunespleen   highly
    Reproductivemale systemtestis  highly Homo sapiens
    Skin/Tegumentskin   highly
    Urinarykidney   highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal C3HC4 RING finger motif
  • three zinc-fingers and an UIM motif
  • two C2H2(Krueppel) zinc finger motifs at the C terminus
  • conjugated MetalloP
    HOMOLOGY
    intraspecies paralog to NCOR2, an ubiquitin ligase regulating T-cell activation
    paralog to RNF125
    Homologene
    FAMILY
  • RING domain E3 ubiquitin ligases family
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    text
  • localizes predominantly to the cytoplasm
  • shows both the nuclear and cytoplasmic localization in epithelial cells of normal tissues, but exhibits an intense cytoplasmic distribution in carcinoma cells of tumor tissues
  • basic FUNCTION
  • potential transcription regulator
  • may play a role in human spermatogenesis and male fertility
  • polyubiquitin binding protein involved in NF-kappaB signaling
  • is potentially controlled at the transcriptional level, and a common mechanism controlling its basal transcription exists
  • having a putative role in the regulation of immune responses
  • regulates a positive feedback loop that enhances dsRNA induced production of type I IFN
  • positive regulator of innate immune pathway, suggesting that this gene may contribute to psoriasis susceptibility by up-regulating the production of type I IFN
  • cytoplasmic soluble protein, which is compatible with a function in IFIH1/DDX58 signalling
  • ubiquitin E3 ligase that has a critical role in the regulation of cell cycle progression, differentiation and senescence
  • activates cell cycle progression and suppresses cellular senescence through the RING domain-mediated degradation of CDKN1A
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binds ubiquitin via an ubiquitin-interaction motif (UIM)
  • associates with ubiquitinated proteins and it is a soluble cytosolic protein that can be induced by interferons and synthetic dsRNA (double-stranded RNA)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to psoriasis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS