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FLASH GENE
Symbol RNF111 contributors: mct - updated : 02-09-2014
HGNC name ring finger protein 111
HGNC id 17384
Location 15q21      Physical location : 59.279.864 - 59.389.251
Synonym name Arkadia
Synonym symbol(s) ARK, FLJ38008, DKFZp761D081, DKFZp313E0731
EC.number 6.3.2.-
DNA
TYPE functioning gene
STRUCTURE 109.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 5929 - 995 - 2010 20965945
14 - 5902 - 986 - 2010 20965945
14 - 5899 - 985 - 2010 20965945
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Endocrinepancreas    
Lymphoid/Immunespleen    
Reproductivemale systemtestis   
Respiratorylung    
 respiratory tractlarynx   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • NLS in the N-terminal region
  • a RING finger domain
  • three successive SUMO-interacting motifs (SIMs) that mediate noncovalent interaction with poly-SUMO2
  • HOMOLOGY
    interspecies ortholog to murine Rnf111
    ortholog to rattus Rnf111_predicted
    Homologene
    FAMILY zinc finger family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • colocalized with SMAD7 in the cytoplasm
  • located in both the nucleus and the cytosol in mammalian cells
  • basic FUNCTION
  • may be an E3 ubiquitin ligase
  • enhances both TGF-beta and bone morphogenetic protein (BMP) signaling
  • acting as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development
  • plays a crucial role in the transmission of transforming growth factor beta (TGFB)/activin and bone morphogenetic protein (BMP) signaling
  • critically required for TGF-beta signaling during epithelial to mesenchymal cell transition
  • regulates myoblast differentiation through both Smad-dependent and Smad-independent pathways
  • appears to regulate EGF signalling by modulating endocytosis of EGFR through interaction with AP2 complex
  • is not critical for regulating tumor growth per se, but is required for the early stages of cancer cell colonization at the sites of metastasis
  • can function as a SUMO-targeted ubiquitin ligase (STUBL) by ubiquitinating SUMO chains
  • is a novel STUBL that can trigger degradation of signal-induced polysumoylated proteins
  • facilitated NER by regulating the recruitment of XPC to UV-damaged DNA
  • ubiquitin ligase in the transforming growth factor beta (TGFb) pathway
  • its activity in transcriptional control may depend on the epigenetic context, defined by Polycomb repressive complexes and DNA methylation
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Zn2+
    protein
  • AXIN1 activates TGF-beta signaling by forming a multimeric complex consisting of SMAD7 and ubiquitin E3 ligase RNF111
  • stimulates renal tubular epithelial to mesenchymal cell transition through degradation of SMAD7
  • AP2M1 is an interacting partner of RNF111
  • RB1CC1/FIP200 is a novel positive regulator of TGFB signaling that functions as a substrate-selective cofactor of RNF111
  • binds and synergistically cooperates with RNF111 to activate SMAD3/SMAD4-dependent transcription
  • promoted ubiquitylation of SUMOylated XPC (xeroderma pigmentosum C) protein, a central DNA damage recognition factor in nucleotide excision repair (NER)
  • cell & other
    REGULATION
    repressed by TGF-beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse RNF111 genetically interacts with the TGF beta-like factor Nodal