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FLASH GENE
Symbol RNF103-CHMP3 contributors: mct - updated : 04-06-2019
HGNC name RNF103-CHMP3 readthrough
HGNC id 29865
Location 2p11.2      Physical location : -
Synonym name
  • vacuolar protein sorting 24 (yeast)
  • neuroendocrine differentiation factor
  • comparative gene identification transcript 149
  • chromatin-modifying protein 3
  • RNF103-VPS24 readthrough
  • Synonym symbol(s) 25.1, NEDF, CGI-149, CHMP3, VPS24, CGI149, RNF103-VPS24, FLJ58988
    DNA
    TYPE functioning gene
    STRUCTURE 217.69 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3373 - 251 - 2008 1878639
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue   
    Lymphoid/Immunespleen    
    Nervousbrainhindbraincerebellum highly
     nerve    
    Reproductivefemale systembreastmammary gland highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal fragments of all ESCRT-III proteins, including CHMP2A, CHMP1B, VPS24, CHMP4A, CHMP6, and CHMP5, activated VPS4A suggesting that it disassembles ESCRT-III heteropolymers by affecting each component protein
  • HOMOLOGY
    Homologene
    FAMILY
  • SNF7 family
  • chromatin-modifying protein/charged multivesicular body protein (CHMP) family
  • CATEGORY secretory , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localized mainly to late endosomes
  • localize to kinetochores
  • basic FUNCTION
  • acting in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway
  • required for degradation but not silencing of the epidermal growth factor receptor
  • with CHM6, CHM4A, CHM4B, CHM4C, are sufficient to detach intralumenal vesicles
  • VPS28, VPS24, and VPS25 are required for dendrite stabilization in mature neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ESCRT-III (CHMP) proteins pathhway
    a component with CHMP2A, copolymerized in solution, and their membrane targeting was cooperatively enhanced on planar lipid bilayers
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding between VTA1 and ESCRT-III proteins (CHMP1B, CHMP2A, VPS24) that is likely to complement VTA1 previously described ability to regulate VPS4 activity
  • tight coupling of ESCRT-III CHMP3 and STAMBP functions and provide insight into the regulation of ESCRT-III
  • CSNK2A1 is involved in the phosphorylation of the ESCRT-III subunits CHMP3 and CHMP2B, as well as of VPS4B/SKD1, an ATPase that mediates ESCRT-III disassembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS