protein
| binding to socius (UBXD5) |
|
bind and inhibit rho kinase-1 (ROCK1) (induces neurite-like formation through inhibition of the RHOA/ROCK1 signalling)  |
|
inhibits the phosphorylation of the translational repressor EIF4EBP1 in response to extracellular stimuli  |
|
also inhibits the expression and the transcriptional activity of the EIF4E target MYC  |
|
negatively regulates PLEKHG5, and that as a RhoA-GEF it plays a key role in early embryonic cell shape changes  |
|
with RND1 both antagonise RhoA/ROCK-mediated actomyosin contractility, thereby regulating cell migration, smooth muscle contractility and neurite extension  |
|
RND1, RND2, RND3 bind directly to ARHGAP35 and equally induce activation of ARHGAP35 (pMID: 22357615) |
|
PLEKHG5 is a RND3 effector that interacts with RNDs via a RAF1-like Ras-binding domain  |
|
acts by increasing RHOB expression, which is then required for RND3-induced stress fibre assembly  |
|
PLXNB1 binds in a GTP-dependent manner to RAC1, RAC2, RAC3, RND1, RND2, RND3, and RHOD  |
|
PLXNB2 competes with ARHGAP35 for binding to RND3, thus blocking the RND3-mediated inhibition of RHOA and also recruits RhoGEFs to directly stimulate RHOA activity  |