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FLASH GENE
Symbol RND2 contributors: mct/npt - updated : 13-01-2015
HGNC name Rho family GTPase 2
HGNC id 18315
Location 17q21.31      Physical location : 41.177.257 - 41.184.057
Synonym name
  • homolog to the rho family of GTP binding proteins
  • ras homolog gene family, member N
  • GTP-binding protein Rho7
  • Synonym symbol(s) RH07, ARHN, RhoN
    DNA
    TYPE functioning gene
    STRUCTURE 6.80 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located located just centromeric to BRCA1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4169 - 227 - 2002 11931639
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary   
     parathyroid    
    Nervousbrain    
    Reproductivemale systemtestis  highly
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated LipoP , Other
    HOMOLOGY
    interspecies homolog to murine Arhn
    homolog to C.elegans rhr-1
    intraspecies homolog to rho family (of GTP binding proteins)
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rho family
  • Rnd subfamily
  • CATEGORY regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • GTPase, specifically involved in neuronal and hepatic functions
  • involved in the regulation of endosomal trafficking via direct binding to VPS4A
  • essential regulator of neuronal migration in the cerebral cortex and is a major effector of NEUROG2 function in the promotion of migration
  • regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to RND1 and RND3 inhibiting RhoA signaling (Tanaka 2006)
  • FNBP1 and RND2 cooperatively regulate spine density
  • RND1, RND2, and RND3 are well known as key regulators of the actin cytoskeleton in various cell types, but they comprise a distinct subgroup of the RHO family in that they are GTP bound and constitutively active (pMID: 22357615)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • binding to the C terminus of SOC
  • binding VPS4A
  • interacting with NEUROG2
  • RND2, binds to the HR1 domain of Rapostlin (FNBP1) (enhanced the Rapostlin-induced tubular membrane invagination)
  • expression of RND2, a modulator of radial migration, is complementary to both these gradients and strongly increases in the absence of NR2F1 function
  • RND1, RND2, RND3 bind directly to ARHGAP35 and equally induce activation of ARHGAP35
  • RND1, RND2, and RND3 stability is acutely dependent on interaction with their effectors such as PLEKHG5 or ARHGAP35
  • ZBTB18 represses NEUROG2 transcription to regulate the NEUROG2-RND2 pathway
  • PLXNB1 binds in a GTP-dependent manner to RAC1, RAC2, RAC3, RND1, RND2, RND3, and RHOD
  • KCTD13 and TNFAIP1 are interacting partners to RND proteins which influence the development of cortical neurons
  • cell & other
    REGULATION
    inhibited by ZBTB18 (negative regulation of RND2 by ZBTB18 was important for cortical cell migration
    repressed by NR2F1 (directly represses RND2 expression at the post-mitotic level along the rostrocaudal axis of the neocortex) (PMId: 21965613)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS